GPR32 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR32 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR32
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 32
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2854|2854]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75388|O75388]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR32&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR32|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603195|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Orphan receptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-formyl peptide receptor activity|
|complement receptor mediated signaling pathway|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|cellular calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|inflammatory response|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|ion homeostasis|
|positive regulation of immune response|
|cellular homeostasis|
|chemical homeostasis|
|regulation of immune response|
|positive regulation of immune system process|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|homeostatic process|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.79|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.82|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.61|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14631
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR32 Expression in NALM6 Cells: -3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>