GPR89B [The Human Chemical-Genetic Interaction Map Project]

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======= GPR89B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR89B
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 89B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51463|51463]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0CG08|P0CG08]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR89B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR89B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612806|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3735|
|ABA GPCR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|voltage-gated anion channel activity|
|intracellular pH reduction|
|pH reduction|
|regulation of intracellular pH|
|regulation of cellular pH|
|Golgi cisterna membrane|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|monovalent inorganic cation homeostasis|
|inorganic anion transport|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|anion transport|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|ion transmembrane transport|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.8|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.79|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chka|CHKA]]|0.436|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5042
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR89B Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>