GPSM2 [The Human Chemical-Genetic Interaction Map Project]

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======= GPSM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPSM2
  * **<color #00a2e8>Official Name</color>**: G protein signaling modulator 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29899|29899]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P81274|P81274]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPSM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPSM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609245|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein- dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays also an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 1|
|GoLoco|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lateral cell cortex|
|Ran protein signal transduction|
|positive regulation of spindle assembly|
|positive regulation of protein localization to cell cortex|
|maintenance of centrosome location|
|regulation of protein localization to cell cortex|
|GDP-dissociation inhibitor activity|
|maintenance of organelle location|
|cell cortex region|
|dynein complex binding|
|G-protein alpha-subunit binding|
|mitotic spindle pole|
|establishment of mitotic spindle orientation|
|centrosome localization|
|regulation of spindle assembly|
|microtubule organizing center localization|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|regulation of mitotic spindle organization|
|establishment of spindle localization|
|regulation of spindle organization|
|spindle localization|
|protein self-association|
|lateral plasma membrane|
|positive regulation of protein localization to cell periphery|
|nucleotide binding|
|positive regulation of organelle assembly|
|mitotic spindle organization|
|maintenance of location in cell|
|microtubule cytoskeleton organization involved in mitosis|
|regulation of protein localization to cell periphery|
|establishment of cell polarity|
|cell cortex|
|spindle organization|
|maintenance of location|
|protein C-terminus binding|
|regulation of microtubule cytoskeleton organization|
|establishment or maintenance of cell polarity|
|positive regulation of cytoskeleton organization|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|protein domain specific binding|
|Ras protein signal transduction|
|positive regulation of cell cycle process|
|small GTPase mediated signal transduction|
|positive regulation of cellular protein localization|
|establishment of organelle localization|
|positive regulation of cell cycle|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|cell cycle process|
|regulation of protein localization|
|identical protein binding|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|cell cycle|
|intracellular signal transduction|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6592
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPSM2 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>