GRAMD1A [The Human Chemical-Genetic Interaction Map Project]

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======= GRAMD1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRAMD1A
  * **<color #00a2e8>Official Name</color>**: GRAM domain containing 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57655|57655]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CP6|Q96CP6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRAMD1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRAMD1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620178|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in tumor progression. {ECO:0000269|PubMed:27585821}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GRAM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|organelle membrane contact site|
|endoplasmic reticulum-plasma membrane contact site|
|intrinsic component of endoplasmic reticulum membrane|
|cellular response to cholesterol|
|cholesterol transfer activity|
|cellular response to sterol|
|response to cholesterol|
|response to sterol|
|cholesterol binding|
|extrinsic component of cytoplasmic side of plasma membrane|
|sterol transport|
|cellular response to alcohol|
|organic hydroxy compound transport|
|response to alcohol|
|lipid transport|
|lipid localization|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|response to lipid|
|response to organic cyclic compound|
|cellular response to oxygen-containing compound|
|response to oxygen-containing compound|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.77|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.472|
|[[:human genes:d:dock6|DOCK6]]|0.437|
|[[:human genes:a:acbd4|ACBD4]]|0.429|
|[[:human genes:c:cdh24|CDH24]]|0.417|
|[[:human genes:c:cln6|CLN6]]|0.415|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.414|
|[[:human genes:p:psmb2|PSMB2]]|0.411|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.407|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.402|
|[[:human genes:a:akirin2|AKIRIN2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2774
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRAMD1A Expression in NALM6 Cells: 6.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>