GRB14 [The Human Chemical-Genetic Interaction Map Project]

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======= GRB14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRB14
  * **<color #00a2e8>Official Name</color>**: growth factor receptor bound protein 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2888|2888]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14449|Q14449]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRB14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRB14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601524|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|RA|
|SH2|
|BPS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|SH3/SH2 adaptor activity|
|receptor tyrosine kinase binding|
|regulation of insulin receptor signaling pathway|
|regulation of cellular response to insulin stimulus|
|insulin receptor signaling pathway|
|cellular response to insulin stimulus|
|endosome membrane|
|response to insulin|
|cellular response to peptide hormone stimulus|
|cellular response to peptide|
|leukocyte migration|
|response to peptide hormone|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|enzyme linked receptor protein signaling pathway|
|protein homodimerization activity|
|response to hormone|
|cell migration|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|identical protein binding|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-2|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.79|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.71|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18670
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRB14 Expression in NALM6 Cells: -3.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>