GREB1L [The Human Chemical-Genetic Interaction Map Project]

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======= GREB1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GREB1L
  * **<color #00a2e8>Official Name</color>**: GREB1 like retinoic acid receptor coactivator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80000|80000]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C091|Q9C091]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GREB1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GREB1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617782|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a major role in early metanephros and genital development. {ECO:0000269|PubMed:29100091}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|paramesonephric duct development|
|mesonephric duct development|
|nephric duct development|
|uterus development|
|male genitalia development|
|branching involved in ureteric bud morphogenesis|
|genitalia development|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|nephron tubule development|
|renal tubule development|
|metanephros development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|mesonephros development|
|nephron epithelium development|
|nephron development|
|cardiac ventricle development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|male sex differentiation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|cardiac chamber development|
|sex differentiation|
|kidney development|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|heart development|
|tissue morphogenesis|
|tube morphogenesis|
|developmental process involved in reproduction|
|tube development|
|circulatory system development|
|animal organ morphogenesis|
|epithelium development|
|reproductive process|
|reproduction|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11295
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GREB1L Expression in NALM6 Cells: 1.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>