GREM2 [The Human Chemical-Genetic Interaction Map Project]

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======= GREM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GREM2
  * **<color #00a2e8>Official Name</color>**: gremlin 2, DAN family BMP antagonist
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64388|64388]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H772|Q9H772]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GREM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GREM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608832|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. {ECO:0000250|UniProtKB:O88273}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequestering of BMP from receptor via BMP binding|
|regulation of cytokine activity|
|determination of dorsal identity|
|determination of dorsal/ventral asymmetry|
|embryonic body morphogenesis|
|sequestering of extracellular ligand from receptor|
|BMP binding|
|extracellular regulation of signal transduction|
|extracellular negative regulation of signal transduction|
|regulation of receptor binding|
|body morphogenesis|
|negative regulation of BMP signaling pathway|
|dorsal/ventral pattern formation|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|determination of bilateral symmetry|
|specification of symmetry|
|negative regulation of cellular response to growth factor stimulus|
|heparin binding|
|regulation of signaling receptor activity|
|cytokine activity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of protein binding|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|regionalization|
|regulation of binding|
|pattern specification process|
|cellular response to growth factor stimulus|
|response to growth factor|
|embryonic morphogenesis|
|cytokine-mediated signaling pathway|
|enzyme linked receptor protein signaling pathway|
|protein homodimerization activity|
|embryo development|
|cellular response to cytokine stimulus|
|response to cytokine|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|extracellular space|
|negative regulation of response to stimulus|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.11|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.98|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.84|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.7|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7954
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GREM2 Expression in NALM6 Cells: 0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>