GRIA1 [The Human Chemical-Genetic Interaction Map Project]

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======= GRIA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIA1
  * **<color #00a2e8>Official Name</color>**: glutamate ionotropic receptor AMPA type subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2890|2890]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42261|P42261]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138248|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SBP bac 3|
|ANF receptor|
|Lig chan-Glu bd|
|Lig chan|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration|
|axonal spine|
|AMPA glutamate receptor activity|
|neuron spine|
|regulation of postsynaptic cytosolic calcium ion concentration|
|dendritic spine membrane|
|glutamate receptor activity|
|long-term synaptic depression|
|ionotropic glutamate receptor signaling pathway|
|synaptic membrane|
|AMPA glutamate receptor complex|
|long-term memory|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|regulation of NMDA receptor activity|
|glutamate receptor signaling pathway|
|integral component of postsynaptic density membrane|
|ER to Golgi transport vesicle membrane|
|negative regulation of synaptic transmission|
|receptor internalization|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|regulation of glutamate receptor signaling pathway|
|vesicle coating|
|endocytic vesicle membrane|
|COPII-coated vesicle budding|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle targeting, to, from or within Golgi|
|regulation of neurotransmitter receptor activity|
|Golgi vesicle budding|
|amyloid-beta binding|
|recycling endosome membrane|
|PDZ domain binding|
|vesicle targeting|
|vesicle budding from membrane|
|regulation of postsynaptic membrane potential|
|receptor metabolic process|
|recycling endosome|
|memory|
|synaptic vesicle|
|dendritic spine|
|early endosome membrane|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|establishment of vesicle localization|
|vesicle localization|
|regulation of synaptic plasticity|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|receptor-mediated endocytosis|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|cognition|
|vesicle organization|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|establishment of organelle localization|
|neuronal cell body|
|Golgi vesicle transport|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|dendrite|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|cell junction|
|endocytosis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|behavior|
|organelle localization|
|cell surface|
|Golgi membrane|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|membrane organization|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|intracellular transport|
|protein-containing complex assembly|
|homeostatic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.28|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13205
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIA1 Expression in NALM6 Cells: 0.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>