GRID2IP [The Human Chemical-Genetic Interaction Map Project]

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======= GRID2IP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRID2IP
  * **<color #00a2e8>Official Name</color>**: Grid2 interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=392862|392862]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A4D2P6|A4D2P6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRID2IP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRID2IP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610639|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FH2|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|long-term synaptic depression|
|negative regulation of synaptic transmission|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cell junction|
|negative regulation of cell communication|
|negative regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.83|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.79|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.88|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.91|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.1|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.13|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.81|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.92|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.03|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.09|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3802
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRID2IP Expression in NALM6 Cells: 2.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>