GRM2 [The Human Chemical-Genetic Interaction Map Project]

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======= GRM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRM2
  * **<color #00a2e8>Official Name</color>**: glutamate metabotropic receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2912|2912]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14416|Q14416]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604099|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:7620613}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 3|
|NCD3G|
|ANF receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|group II metabotropic glutamate receptor activity|
|glutamate homeostasis|
|amino acid homeostasis|
|adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway|
|G protein-coupled glutamate receptor signaling pathway|
|glutamate receptor activity|
|negative regulation of adenylate cyclase activity|
|negative regulation of cyclase activity|
|negative regulation of lyase activity|
|regulation of adenylate cyclase activity|
|glutamate secretion|
|calcium channel regulator activity|
|regulation of cyclase activity|
|integral component of postsynaptic membrane|
|regulation of lyase activity|
|glutamate receptor signaling pathway|
|acidic amino acid transport|
|anion homeostasis|
|regulation of synaptic transmission, glutamatergic|
|presynaptic membrane|
|dicarboxylic acid transport|
|acid secretion|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|amino acid transport|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|organic acid transport|
|carboxylic acid transport|
|axon|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|dendrite|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|cell junction|
|anion transport|
|G protein-coupled receptor activity|
|ion homeostasis|
|negative regulation of catalytic activity|
|secretion by cell|
|export from cell|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|negative regulation of molecular function|
|G protein-coupled receptor signaling pathway|
|ion transport|
|integral component of plasma membrane|
|homeostatic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7408
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRM2 Expression in NALM6 Cells: 0.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>