GRM8 [The Human Chemical-Genetic Interaction Map Project]

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======= GRM8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRM8
  * **<color #00a2e8>Official Name</color>**: glutamate metabotropic receptor 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2918|2918]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00222|O00222]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRM8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRM8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601116|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NCD3G|
|ANF receptor|
|7tm 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway|
|G protein-coupled glutamate receptor signaling pathway|
|glutamate receptor activity|
|glutamate receptor signaling pathway|
|regulation of synaptic transmission, glutamatergic|
|presynaptic membrane|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|visual perception|
|sensory perception of light stimulus|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|G protein-coupled receptor activity|
|sensory perception|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6019
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRM8 Expression in NALM6 Cells: -3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>