GRXCR1 [The Human Chemical-Genetic Interaction Map Project]

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======= GRXCR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRXCR1
  * **<color #00a2e8>Official Name</color>**: glutaredoxin and cysteine rich domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=389207|389207]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A8MXD5|A8MXD5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRXCR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRXCR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613283|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in actin filament architecture in developing stereocilia of sensory cells. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glutaredoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vestibular receptor cell differentiation|
|vestibular receptor cell development|
|kinocilium|
|protein disulfide oxidoreductase activity|
|inner ear receptor cell stereocilium organization|
|stereocilium|
|hair cell differentiation|
|inner ear receptor cell development|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|microvillus|
|electron transfer activity|
|cell redox homeostasis|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|regulation of phosphatase activity|
|electron transport chain|
|inner ear development|
|regulation of dephosphorylation|
|ear development|
|epidermal cell differentiation|
|epidermis development|
|generation of precursor metabolites and energy|
|negative regulation of hydrolase activity|
|sensory organ development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|neuron projection development|
|epithelial cell differentiation|
|molecular function|
|negative regulation of catalytic activity|
|neuron development|
|cellular homeostasis|
|oxidation-reduction process|
|sensory perception|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of hydrolase activity|
|nervous system process|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.88|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.78|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.73|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.72|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.74|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.86|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14405
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRXCR1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>