GSTP1 [The Human Chemical-Genetic Interaction Map Project]

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======= GSTP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GSTP1
  * **<color #00a2e8>Official Name</color>**: glutathione S-transferase pi 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2950|2950]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09211|P09211]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSTP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSTP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21668448}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GST C|
|GST N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|S-nitrosoglutathione binding|
|dinitrosyl-iron complex binding|
|nitric oxide storage|
|nitric oxide binding|
|TRAF2-GSTP1 complex|
|cellular response to cell-matrix adhesion|
|kinase regulator activity|
|nitric oxide homeostasis|
|negative regulation of nitric-oxide synthase biosynthetic process|
|negative regulation of smooth muscle cell chemotaxis|
|response to L-ascorbic acid|
|negative regulation of monocyte chemotactic protein-1 production|
|regulation of smooth muscle cell chemotaxis|
|common myeloid progenitor cell proliferation|
|JUN kinase binding|
|gas homeostasis|
|glutathione binding|
|negative regulation of acute inflammatory response|
|negative regulation of JUN kinase activity|
|xenobiotic catabolic process|
|regulation of monocyte chemotactic protein-1 production|
|linoleic acid metabolic process|
|negative regulation of vascular smooth muscle cell proliferation|
|negative regulation of chemokine production|
|positive regulation of superoxide anion generation|
|regulation of nitric-oxide synthase biosynthetic process|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|glutathione peroxidase activity|
|regulation of superoxide anion generation|
|negative regulation of smooth muscle cell migration|
|glutathione derivative metabolic process|
|glutathione derivative biosynthetic process|
|negative regulation of interleukin-1 beta production|
|glutathione transferase activity|
|negative regulation of fibroblast proliferation|
|negative regulation of interleukin-1 production|
|regulation of superoxide metabolic process|
|negative regulation of JNK cascade|
|oligodendrocyte development|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to epidermal growth factor stimulus|
|regulation of acute inflammatory response|
|negative regulation of smooth muscle cell proliferation|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|response to epidermal growth factor|
|regulation of vascular smooth muscle cell proliferation|
|glutathione metabolic process|
|cellular response to glucocorticoid stimulus|
|drug binding|
|negative regulation of chemotaxis|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of tumor necrosis factor production|
|cellular response to corticosteroid stimulus|
|regulation of smooth muscle cell migration|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|negative regulation of ERK1 and ERK2 cascade|
|oligodendrocyte differentiation|
|animal organ regeneration|
|negative regulation of MAP kinase activity|
|regulation of chemokine production|
|negative regulation of leukocyte proliferation|
|regulation of interleukin-1 beta production|
|regulation of fibroblast proliferation|
|response to vitamin|
|regulation of JUN kinase activity|
|cellular oxidant detoxification|
|regulation of interleukin-1 production|
|positive regulation of reactive oxygen species metabolic process|
|cellular detoxification|
|negative regulation of extrinsic apoptotic signaling pathway|
|unsaturated fatty acid metabolic process|
|glial cell development|
|response to amino acid|
|long-chain fatty acid metabolic process|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|response to ethanol|
|detoxification|
|xenobiotic metabolic process|
|negative regulation of protein serine/threonine kinase activity|
|regulation of smooth muscle cell proliferation|
|response to estradiol|
|negative regulation of inflammatory response|
|vesicle|
|response to glucocorticoid|
|response to monosaccharide|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of extrinsic apoptotic signaling pathway|
|regeneration|
|response to corticosteroid|
|cellular response to insulin stimulus|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of MAPK cascade|
|glial cell differentiation|
|response to carbohydrate|
|regulation of response to cytokine stimulus|
|regulation of reactive oxygen species metabolic process|
|sulfur compound biosynthetic process|
|cellular response to lipopolysaccharide|
|regulation of JNK cascade|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|cellular response to molecule of bacterial origin|
|response to reactive oxygen species|
|cellular modified amino acid metabolic process|
|negative regulation of defense response|
|regulation of chemotaxis|
|cellular response to toxic substance|
|gliogenesis|
|cellular response to biotic stimulus|
|response to nutrient|
|regulation of leukocyte proliferation|
|negative regulation of protein kinase activity|
|negative regulation of apoptotic signaling pathway|
|response to insulin|
|response to alcohol|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to oxidative stress|
|negative regulation of kinase activity|
|negative regulation of cell migration|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|regulation of ERK1 and ERK2 cascade|
|response to xenobiotic stimulus|
|response to antibiotic|
|negative regulation of cellular component movement|
|response to lipopolysaccharide|
|negative regulation of locomotion|
|fatty acid metabolic process|
|cellular response to peptide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|cellular response to external stimulus|
|regulation of inflammatory response|
|regulation of MAP kinase activity|
|response to acid chemical|
|negative regulation of response to external stimulus|
|sulfur compound metabolic process|
|response to oxidative stress|
|response to peptide hormone|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|cofactor metabolic process|
|negative regulation of phosphorylation|
|response to peptide|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|response to nutrient levels|
|neutrophil mediated immunity|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|response to growth factor|
|cellular response to organic cyclic compound|
|cell population proliferation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|leukocyte activation|
|cellular lipid metabolic process|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|secretion by cell|
|response to drug|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|secretion|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|mitochondrion|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.71|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4479
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSTP1 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>