GTF2E1 [The Human Chemical-Genetic Interaction Map Project]

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======= GTF2E1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF2E1
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIE subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2960|2960]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29083|P29083]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF2E1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF2E1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189962|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIIE alpha|
|TFIIE-A C-term|
|TF Zn Ribbon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcriptional open complex formation at RNA polymerase II promoter|
|protein-DNA complex remodeling|
|DNA-templated transcriptional open complex formation|
|transcription factor TFIIE complex|
|TFIIH-class transcription factor complex binding|
|transcriptional preinitiation complex|
|RNA polymerase II general transcription initiation factor activity|
|protein-containing complex remodeling|
|RNA polymerase II complex binding|
|transcription factor TFIID complex|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|protein-DNA complex subunit organization|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 568/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|23/28|
|bone|20/25|
|breast|25/33|
|central nervous system|47/56|
|cervix|3/4|
|colorectal|13/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|10/15|
|kidney|13/21|
|liver|18/20|
|lung|60/75|
|lymphocyte|12/14|
|ovary|21/26|
|pancreas|21/24|
|peripheral nervous system|10/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|4/7|
|thyroid|2/2|
|upper aerodigestive|11/22|
|urinary tract|17/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1539
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF2E1 Expression in NALM6 Cells: 4.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>