GTF2H2 [The Human Chemical-Genetic Interaction Map Project]

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======= GTF2H2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF2H2
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIH subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2966|2966]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13888|Q13888]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF2H2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF2H2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601748|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre- initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. {ECO:0000269|PubMed:11319235, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:8194529, ECO:0000269|PubMed:9852112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1 4|
|Ssl1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of DNA helicase activity|
|positive regulation of DNA duplex unwinding|
|core TFIIH complex portion of holo TFIIH complex|
|regulation of DNA helicase activity|
|regulation of DNA duplex unwinding|
|positive regulation of helicase activity|
|transcription factor TFIIH core complex|
|transcription factor TFIIH holo complex|
|regulation of helicase activity|
|G protein-coupled receptor internalization|
|RNA polymerase II general transcription initiation factor activity|
|RNA polymerase II CTD heptapeptide repeat kinase activity|
|negative adaptation of signaling pathway|
|desensitization of G protein-coupled receptor signaling pathway|
|adaptation of signaling pathway|
|nucleotide-excision repair, preincision complex stabilization|
|nucleotide-excision repair, DNA incision, 3-to lesion|
|nucleotide-excision repair, DNA duplex unwinding|
|global genome nucleotide-excision repair|
|transcription elongation from RNA polymerase I promoter|
|nucleotide-excision repair, preincision complex assembly|
|termination of RNA polymerase I transcription|
|7-methylguanosine mRNA capping|
|7-methylguanosine RNA capping|
|RNA capping|
|transcription initiation from RNA polymerase I promoter|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|transcription factor TFIID complex|
|transcription by RNA polymerase I|
|nucleotide-excision repair, DNA incision|
|DNA-dependent ATPase activity|
|negative regulation of G protein-coupled receptor signaling pathway|
|positive regulation of ATPase activity|
|receptor internalization|
|DNA-templated transcription, termination|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|regulation of ATPase activity|
|DNA-templated transcription, elongation|
|receptor metabolic process|
|protein N-terminus binding|
|nucleotide-excision repair|
|DNA duplex unwinding|
|DNA geometric change|
|regulation of G protein-coupled receptor signaling pathway|
|response to UV|
|positive regulation of chromosome organization|
|transcription initiation from RNA polymerase II promoter|
|nucleic acid binding|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|receptor-mediated endocytosis|
|protein kinase activity|
|protein-DNA complex subunit organization|
|positive regulation of protein complex assembly|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|regulation of chromosome organization|
|nuclear speck|
|response to radiation|
|regulation of protein complex assembly|
|mRNA processing|
|transcription by RNA polymerase II|
|DNA repair|
|positive regulation of cellular component biogenesis|
|endocytosis|
|positive regulation of organelle organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|import into cell|
|mRNA metabolic process|
|DNA metabolic process|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|cellular protein-containing complex assembly|
|RNA processing|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2147
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF2H2 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>