GTF2H5 [The Human Chemical-Genetic Interaction Map Project]

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======= GTF2H5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF2H5
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIH subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=404672|404672]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZYL4|Q6ZYL4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF2H5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF2H5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608780|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is implicated in regulating cellular levels of TFIIH. Mutations in this gene result in trichothiodystrophy, complementation group A. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre- initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. {ECO:0000269|PubMed:15220921}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tbf5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rDNA binding|
|phosphorylation of RNA polymerase II C-terminal domain|
|transcription factor TFIIH core complex|
|transcription factor TFIIH holo complex|
|nucleotide-excision repair, preincision complex stabilization|
|nucleotide-excision repair, DNA incision, 3-to lesion|
|nucleotide-excision repair, DNA duplex unwinding|
|global genome nucleotide-excision repair|
|nucleotide-excision repair, preincision complex assembly|
|transcription elongation from RNA polymerase I promoter|
|termination of RNA polymerase I transcription|
|cellular response to gamma radiation|
|7-methylguanosine mRNA capping|
|7-methylguanosine RNA capping|
|RNA capping|
|transcription initiation from RNA polymerase I promoter|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|transcription factor TFIID complex|
|transcription by RNA polymerase I|
|nucleotide-excision repair, DNA incision|
|response to gamma radiation|
|cellular response to ionizing radiation|
|DNA-templated transcription, termination|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|nucleotide-excision repair|
|DNA duplex unwinding|
|DNA geometric change|
|response to ionizing radiation|
|cellular response to radiation|
|transcription initiation from RNA polymerase II promoter|
|protein-DNA complex assembly|
|rRNA processing|
|DNA-templated transcription, initiation|
|rRNA metabolic process|
|protein-DNA complex subunit organization|
|positive regulation of protein complex assembly|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|ncRNA processing|
|response to radiation|
|regulation of protein complex assembly|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|transcription by RNA polymerase II|
|DNA repair|
|positive regulation of cellular component biogenesis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.79|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.12|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.91|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.83|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.75|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.74|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.72|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.79|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7866
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF2H5 Expression in NALM6 Cells: 4.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>