GTF3C5 [The Human Chemical-Genetic Interaction Map Project]

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======= GTF3C5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF3C5
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIIC subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9328|9328]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5Q8|Q9Y5Q8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF3C5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF3C5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604890|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tau95|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase III type 1 promoter sequence-specific DNA binding|
|RNA polymerase III transcription regulator recruiting activity|
|RNA polymerase III type 2 promoter sequence-specific DNA binding|
|RNA polymerase III general transcription initiation factor activity|
|5S class rRNA transcription by RNA polymerase III|
|transcription factor TFIIIC complex|
|tRNA transcription by RNA polymerase III|
|RNA polymerase III preinitiation complex assembly|
|tRNA transcription|
|transcription initiation from RNA polymerase III promoter|
|rRNA transcription|
|transcription preinitiation complex assembly|
|transcription by RNA polymerase III|
|skeletal muscle cell differentiation|
|ncRNA transcription|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|protein-DNA complex subunit organization|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle structure development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular protein-containing complex assembly|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.02|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.01|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:trmt5|TRMT5]]|0.491|
|[[:human genes:t:tsen54|TSEN54]]|0.474|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.474|
|[[:human genes:p:polr3h|POLR3H]]|0.462|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.453|
|[[:human genes:a:alg1|ALG1]]|0.452|
|[[:human genes:a:atxn10|ATXN10]]|0.445|
|[[:human genes:r:rtcb|RTCB]]|0.443|
|[[:human genes:d:dpagt1|DPAGT1]]|0.413|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.408|
|[[:human genes:o:osgep|OSGEP]]|0.406|
|[[:human genes:g:gmppb|GMPPB]]|0.401|
|[[:human genes:r:rpp21|RPP21]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/25|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1358
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF3C5 Expression in NALM6 Cells: 6.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>