GTF3C6 [The Human Chemical-Genetic Interaction Map Project]

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======= GTF3C6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF3C6
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIIC subunit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=112495|112495]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969F1|Q969F1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF3C6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF3C6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611784|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. {ECO:0000269|PubMed:17409385}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIIIC sub6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|5S class rRNA transcription by RNA polymerase III|
|transcription factor TFIIIC complex|
|tRNA transcription by RNA polymerase III|
|tRNA transcription|
|rRNA transcription|
|transcription by RNA polymerase III|
|ncRNA transcription|
|nuclear body|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-3.43|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-2.51|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.31|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.19|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.18|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.11|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.94|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.88|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.86|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.82|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.81|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.8|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.78|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.76|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.74|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.72|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.77|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.8|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.8|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.8|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.91|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.06|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.08|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.11|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.2|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.22|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.23|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.25|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.602|
|[[:human genes:u:uap1|UAP1]]|0.585|
|[[:human genes:r:rptor|RPTOR]]|0.581|
|[[:human genes:a:alg1|ALG1]]|0.58|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.568|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.567|
|[[:human genes:r:rnmt|RNMT]]|0.565|
|[[:human genes:u:uhrf1|UHRF1]]|0.562|
|[[:human genes:r:rtcb|RTCB]]|0.558|
|[[:human genes:r:rpp21|RPP21]]|0.558|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.557|
|[[:human genes:d:dpagt1|DPAGT1]]|0.554|
|[[:human genes:s:srp14|SRP14]]|0.55|
|[[:human genes:g:gemin6|GEMIN6]]|0.547|
|[[:human genes:t:triap1|TRIAP1]]|0.54|
|[[:human genes:d:dohh|DOHH]]|0.531|
|[[:human genes:g:gnb1l|GNB1L]]|0.527|
|[[:human genes:t:tamm41|TAMM41]]|0.526|
|[[:human genes:p:pmm2|PMM2]]|0.526|
|[[:human genes:h:hars|HARS]]|0.525|
|[[:human genes:g:gfpt1|GFPT1]]|0.523|
|[[:human genes:t:trmt5|TRMT5]]|0.522|
|[[:human genes:a:atxn10|ATXN10]]|0.521|
|[[:human genes:d:ddx20|DDX20]]|0.518|
|[[:human genes:t:tti2|TTI2]]|0.516|
|[[:human genes:d:dhrsx|DHRSX]]|0.516|
|[[:human genes:d:dpf2|DPF2]]|0.513|
|[[:human genes:r:rpe|RPE]]|0.513|
|[[:human genes:p:ppa2|PPA2]]|0.51|
|[[:human genes:c:cbfb|CBFB]]|0.509|
|[[:human genes:t:trnt1|TRNT1]]|0.508|
|[[:human genes:p:pik3r4|PIK3R4]]|0.507|
|[[:human genes:t:ten1|TEN1]]|0.503|
|[[:human genes:p:pggt1b|PGGT1B]]|0.5|
|[[:human genes:c:cct7|CCT7]]|0.5|
|[[:human genes:g:gmppb|GMPPB]]|0.499|
|[[:human genes:p:ppcs|PPCS]]|0.499|
|[[:human genes:v:vezt|VEZT]]|0.499|
|[[:human genes:e:exoc4|EXOC4]]|0.496|
|[[:human genes:r:rabggtb|RABGGTB]]|0.494|
|[[:human genes:s:ssb|SSB]]|0.494|
|[[:human genes:d:dr1|DR1]]|0.494|
|[[:human genes:a:alg13|ALG13]]|0.493|
|[[:human genes:s:sec61g|SEC61G]]|0.492|
|[[:human genes:t:tti1|TTI1]]|0.491|
|[[:human genes:e:eif3f|EIF3F]]|0.49|
|[[:human genes:f:fh|FH]]|0.489|
|[[:human genes:g:gemin8|GEMIN8]]|0.489|
|[[:human genes:c:cdipt|CDIPT]]|0.486|
|[[:human genes:l:lsm11|LSM11]]|0.484|
|[[:human genes:p:ppp4c|PPP4C]]|0.483|
|[[:human genes:a:aars|AARS]]|0.483|
|[[:human genes:u:urm1|URM1]]|0.482|
|[[:human genes:h:hspd1|HSPD1]]|0.482|
|[[:human genes:w:wdr24|WDR24]]|0.478|
|[[:human genes:t:tsen54|TSEN54]]|0.477|
|[[:human genes:n:nae1|NAE1]]|0.476|
|[[:human genes:a:adsl|ADSL]]|0.476|
|[[:human genes:d:dhps|DHPS]]|0.474|
|[[:human genes:k:kdsr|KDSR]]|0.474|
|[[:human genes:p:polr3h|POLR3H]]|0.473|
|[[:human genes:t:tprkb|TPRKB]]|0.472|
|[[:human genes:t:telo2|TELO2]]|0.472|
|[[:human genes:c:chchd4|CHCHD4]]|0.471|
|[[:human genes:d:dolk|DOLK]]|0.47|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.467|
|[[:human genes:a:atp5j|ATP5J]]|0.466|
|[[:human genes:m:msto1|MSTO1]]|0.465|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.465|
|[[:human genes:t:tmem41b|TMEM41B]]|0.464|
|[[:human genes:g:gemin7|GEMIN7]]|0.464|
|[[:human genes:a:alg6|ALG6]]|0.463|
|[[:human genes:n:nbn|NBN]]|0.463|
|[[:human genes:r:romo1|ROMO1]]|0.462|
|[[:human genes:e:exoc3|EXOC3]]|0.461|
|[[:human genes:h:hccs|HCCS]]|0.46|
|[[:human genes:p:pdap1|PDAP1]]|0.46|
|[[:human genes:e:eif4e|EIF4E]]|0.46|
|[[:human genes:t:txnl4b|TXNL4B]]|0.46|
|[[:human genes:u:ube2g2|UBE2G2]]|0.459|
|[[:human genes:h:haus8|HAUS8]]|0.455|
|[[:human genes:s:slc25a26|SLC25A26]]|0.455|
|[[:human genes:b:bap1|BAP1]]|0.454|
|[[:human genes:a:atp5b|ATP5B]]|0.452|
|[[:human genes:r:rbmx2|RBMX2]]|0.452|
|[[:human genes:p:pelo|PELO]]|0.451|
|[[:human genes:v:vrk1|VRK1]]|0.451|
|[[:human genes:g:gemin5|GEMIN5]]|0.45|
|[[:human genes:p:ppp6c|PPP6C]]|0.45|
|[[:human genes:s:spr|SPR]]|0.449|
|[[:human genes:t:taz|TAZ]]|0.449|
|[[:human genes:e:elac2|ELAC2]]|0.447|
|[[:human genes:c:cbx3|CBX3]]|0.447|
|[[:human genes:a:atp5a1|ATP5A1]]|0.446|
|[[:human genes:e:eny2|ENY2]]|0.445|
|[[:human genes:e:elp3|ELP3]]|0.445|
|[[:human genes:t:taf1a|TAF1A]]|0.441|
|[[:human genes:m:mars|MARS]]|0.44|
|[[:human genes:a:atp5o|ATP5O]]|0.44|
|[[:human genes:w:wdr59|WDR59]]|0.439|
|[[:human genes:s:snf8|SNF8]]|0.439|
|[[:human genes:d:ddx55|DDX55]]|0.438|
|[[:human genes:a:atrx|ATRX]]|0.437|
|[[:human genes:b:bcs1l|BCS1L]]|0.435|
|[[:human genes:t:ttc4|TTC4]]|0.435|
|[[:human genes:u:uxt|UXT]]|0.435|
|[[:human genes:s:stt3a|STT3A]]|0.431|
|[[:human genes:o:otud5|OTUD5]]|0.429|
|[[:human genes:s:srp72|SRP72]]|0.429|
|[[:human genes:e:eno1|ENO1]]|0.429|
|[[:human genes:m:med16|MED16]]|0.428|
|[[:human genes:t:tufm|TUFM]]|0.427|
|[[:human genes:a:apaf1|APAF1]]|0.427|
|[[:human genes:t:tbca|TBCA]]|0.427|
|[[:human genes:c:c17orf89|C17orf89]]|0.427|
|[[:human genes:r:rpia|RPIA]]|0.427|
|[[:human genes:d:dhdds|DHDDS]]|0.426|
|[[:human genes:t:trmt10a|TRMT10A]]|0.426|
|[[:human genes:l:lsm10|LSM10]]|0.426|
|[[:human genes:r:rfk|RFK]]|0.425|
|[[:human genes:a:alg5|ALG5]]|0.425|
|[[:human genes:v:vma21|VMA21]]|0.425|
|[[:human genes:t:trmt61a|TRMT61A]]|0.424|
|[[:human genes:d:dad1|DAD1]]|0.422|
|[[:human genes:m:mrps14|MRPS14]]|0.419|
|[[:human genes:c:cep57|CEP57]]|0.418|
|[[:human genes:m:mllt1|MLLT1]]|0.418|
|[[:human genes:m:mrps33|MRPS33]]|0.417|
|[[:human genes:p:plaa|PLAA]]|0.417|
|[[:human genes:y:yars|YARS]]|0.416|
|[[:human genes:r:rad1|RAD1]]|0.415|
|[[:human genes:m:med23|MED23]]|0.415|
|[[:human genes:u:uba5|UBA5]]|0.415|
|[[:human genes:n:nars|NARS]]|0.414|
|[[:human genes:y:yars2|YARS2]]|0.414|
|[[:human genes:s:sumo2|SUMO2]]|0.414|
|[[:human genes:s:slc35b1|SLC35B1]]|0.414|
|[[:human genes:e:eef1e1|EEF1E1]]|0.413|
|[[:human genes:r:rft1|RFT1]]|0.413|
|[[:human genes:c:crls1|CRLS1]]|0.413|
|[[:human genes:u:uba3|UBA3]]|0.413|
|[[:human genes:n:nsmce1|NSMCE1]]|0.413|
|[[:human genes:o:oip5|OIP5]]|0.411|
|[[:human genes:t:tkt|TKT]]|0.41|
|[[:human genes:u:utp23|UTP23]]|0.41|
|[[:human genes:c:ccdc101|CCDC101]]|0.409|
|[[:human genes:s:snapc5|SNAPC5]]|0.409|
|[[:human genes:z:zrsr2|ZRSR2]]|0.408|
|[[:human genes:c:ctc1|CTC1]]|0.407|
|[[:human genes:s:srprb|SRPRB]]|0.407|
|[[:human genes:p:polr3c|POLR3C]]|0.405|
|[[:human genes:l:lsmd1|LSMD1]]|0.404|
|[[:human genes:t:timm13|TIMM13]]|0.403|
|[[:human genes:w:wdr92|WDR92]]|0.402|
|[[:human genes:m:mrp63|MRP63]]|0.402|
|[[:human genes:m:mrpl21|MRPL21]]|0.401|
|[[:human genes:s:sars2|SARS2]]|0.401|
|[[:human genes:s:sec62|SEC62]]|0.401|
|[[:human genes:t:tsen34|TSEN34]]|0.4|
|[[:human genes:t:timm22|TIMM22]]|0.4|
|[[:human genes:u:ube2m|UBE2M]]|0.4|
|[[:human genes:m:mtor|MTOR]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 110/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|4/25|
|breast|6/33|
|central nervous system|12/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|3/15|
|kidney|2/21|
|liver|5/20|
|lung|9/75|
|lymphocyte|1/14|
|ovary|3/26|
|pancreas|4/24|
|peripheral nervous system|2/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|8/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6270
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF3C6 Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>