GTPBP4 [The Human Chemical-Genetic Interaction Map Project]

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======= GTPBP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTPBP4
  * **<color #00a2e8>Official Name</color>**: GTP binding protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23560|23560]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZE4|Q9BZE4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTPBP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTPBP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619169|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the biogenesis of the 60S ribosomal subunit. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NOGCT|
|Miro|
|FeoB N|
|MMR HSR1|
|NOG1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of collagen binding|
|regulation of collagen binding|
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|negative regulation of DNA replication|
|ribosomal large subunit biogenesis|
|negative regulation of protein ubiquitination|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|regulation of DNA replication|
|osteoblast differentiation|
|negative regulation of binding|
|negative regulation of cell-cell adhesion|
|protein stabilization|
|regulation of protein ubiquitination|
|rRNA processing|
|rRNA metabolic process|
|regulation of protein modification by small protein conjugation or removal|
|nuclear membrane|
|negative regulation of cell migration|
|ossification|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|regulation of protein stability|
|ribosome biogenesis|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|GTPase activity|
|regulation of binding|
|ncRNA processing|
|GTP binding|
|regulation of cell-cell adhesion|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|regulation of protein serine/threonine kinase activity|
|negative regulation of protein modification process|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|regulation of protein kinase activity|
|regulation of cell migration|
|nucleolus|
|regulation of kinase activity|
|RNA processing|
|regulation of cell motility|
|regulation of transferase activity|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.8|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.38|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.02|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.87|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.86|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.84|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.77|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.81|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.84|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.13|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|2.16|
|[[:results:exp453|B02 10μM R08 exp453]]|2.19|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.19|
|[[:results:exp303|39°C R06 exp303]]|2.35|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.439|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 684/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|25/28|
|bone|25/26|
|breast|28/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|19/21|
|liver|19/20|
|lung|70/75|
|lymphocyte|14/16|
|ovary|24/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 627
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTPBP4 Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>