GUCY1B3 [The Human Chemical-Genetic Interaction Map Project]

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======= GUCY1B3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GUCY1B1
  * **<color #00a2e8>Official Name</color>**: guanylate cyclase 1 soluble subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2983|2983]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02153|Q02153]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GUCY1B3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GUCY1B3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139397|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. {ECO:0000250|UniProtKB:P16068, ECO:0000269|PubMed:1352257}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HNOBA|
|HNOB|
|Guanylate cyc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trans-synaptic signaling by nitric oxide, modulating synaptic transmission|
|nitric oxide-cGMP-mediated signaling pathway|
|trans-synaptic signaling by soluble gas, modulating synaptic transmission|
|guanylate cyclase complex, soluble|
|trans-synaptic signaling by soluble gas|
|synaptic signaling by nitric oxide|
|trans-synaptic signaling by nitric oxide|
|guanylate cyclase activity|
|trans-synaptic signaling, modulating synaptic transmission|
|cGMP biosynthetic process|
|cellular response to nitric oxide|
|cGMP metabolic process|
|response to nitric oxide|
|cellular response to reactive nitrogen species|
|nitric oxide mediated signal transduction|
|cyclic purine nucleotide metabolic process|
|cyclic nucleotide biosynthetic process|
|cGMP-mediated signaling|
|presynaptic active zone|
|cyclic nucleotide metabolic process|
|response to bronchodilator|
|cellular response to reactive oxygen species|
|heme binding|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|response to reactive oxygen species|
|signaling receptor activity|
|cellular response to inorganic substance|
|cellular response to oxidative stress|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|purine-containing compound metabolic process|
|response to oxidative stress|
|GTP binding|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|synaptic signaling|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|cellular response to nitrogen compound|
|organophosphate metabolic process|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|cell-cell signaling|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.7|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18452
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GUCY1B3 Expression in NALM6 Cells: -2.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>