GYPE [The Human Chemical-Genetic Interaction Map Project]

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======= GYPE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GYPE
  * **<color #00a2e8>Official Name</color>**: glycophorin E (MNS blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2996|2996]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15421|P15421]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GYPE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GYPE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008].  Sequence Note: This RefSeq record represents the GYPE*0010101 allele. 
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is a minor sialoglycoprotein in human erythrocyte membranes.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integral component of plasma membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-2.09|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.8|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.78|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.7|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.7|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.75|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.8|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.02|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.34|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.49|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GYPE Expression in NALM6 Cells: 1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>