HAAO [The Human Chemical-Genetic Interaction Map Project]

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======= HAAO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HAAO
  * **<color #00a2e8>Official Name</color>**: 3-hydroxyanthranilate 3,4-dioxygenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23498|23498]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46952|P46952]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HAAO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HAAO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. {ECO:0000255|HAMAP- Rule:MF_03019, ECO:0000269|PubMed:7514594}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|3-HAO|
|Cupin 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-hydroxyanthranilate 3,4-dioxygenase activity|
|quinolinate biosynthetic process|
|anthranilate metabolic process|
|quinolinate metabolic process|
|de novo NAD biosynthetic process from tryptophan|
|de novo NAD biosynthetic process|
|tryptophan catabolic process|
|indole-containing compound catabolic process|
|indolalkylamine catabolic process|
|tryptophan metabolic process|
|dicarboxylic acid biosynthetic process|
|indolalkylamine metabolic process|
|cellular biogenic amine catabolic process|
|amine catabolic process|
|indole-containing compound metabolic process|
|ferrous iron binding|
|benzene-containing compound metabolic process|
|aromatic amino acid family catabolic process|
|NAD biosynthetic process|
|nicotinamide nucleotide biosynthetic process|
|pyridine nucleotide biosynthetic process|
|nicotinamide nucleotide metabolic process|
|pyridine nucleotide metabolic process|
|neuron cellular homeostasis|
|pyridine-containing compound biosynthetic process|
|aromatic amino acid family metabolic process|
|pyridine-containing compound metabolic process|
|oxidoreduction coenzyme metabolic process|
|response to zinc ion|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|response to cadmium ion|
|amine metabolic process|
|electron transfer activity|
|water-soluble vitamin metabolic process|
|dicarboxylic acid metabolic process|
|alpha-amino acid catabolic process|
|vitamin metabolic process|
|cellular amino acid catabolic process|
|coenzyme biosynthetic process|
|electron transport chain|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|anatomical structure homeostasis|
|response to metal ion|
|generation of precursor metabolites and energy|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|cellular homeostasis|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7159
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HAAO Expression in NALM6 Cells: -0.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>