HADHB [The Human Chemical-Genetic Interaction Map Project]

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======= HADHB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HADHB
  * **<color #00a2e8>Official Name</color>**: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3032|3032]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55084|P55084]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HADHB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HADHB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/143450|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thiolase C|
|ketoacyl-synt|
|Thiolase N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetyl-CoA C-myristoyltransferase activity|
|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|
|long-chain-enoyl-CoA hydratase activity|
|acetyl-CoA C-acyltransferase activity|
|cardiolipin acyl-chain remodeling|
|mitochondrial envelope|
|enoyl-CoA hydratase activity|
|3-hydroxyacyl-CoA dehydrogenase activity|
|cardiolipin metabolic process|
|phosphatidylglycerol metabolic process|
|mitochondrial nucleoid|
|fatty acid beta-oxidation|
|fatty acid oxidation|
|lipid oxidation|
|fatty acid catabolic process|
|monocarboxylic acid catabolic process|
|mitochondrial outer membrane|
|cellular lipid catabolic process|
|lipid modification|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|fatty acid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|mitochondrial inner membrane|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|lipid metabolic process|
|mitochondrion|
|RNA binding|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.84|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.8|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5389
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HADHB Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>