HARS2 [The Human Chemical-Genetic Interaction Map Project]

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======= HARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HARS2
  * **<color #00a2e8>Official Name</color>**: histidyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23438|23438]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49590|P49590]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600783|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HGTP anticodon|
|HGTP anticodon2|
|tRNA-synt 2b|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histidine-tRNA ligase activity|
|histidyl-tRNA aminoacylation|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|identical protein binding|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.74|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.78|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.86|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.91|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.94|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.01|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.05|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.07|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.675|
|[[:human genes:n:nars2|NARS2]]|0.668|
|[[:human genes:m:mrps14|MRPS14]]|0.668|
|[[:human genes:c:cox16|COX16]]|0.653|
|[[:human genes:d:dap3|DAP3]]|0.651|
|[[:human genes:p:pars2|PARS2]]|0.647|
|[[:human genes:s:selrc1|SELRC1]]|0.644|
|[[:human genes:m:mrps21|MRPS21]]|0.642|
|[[:human genes:m:mrps6|MRPS6]]|0.642|
|[[:human genes:r:rars2|RARS2]]|0.64|
|[[:human genes:m:mrpl21|MRPL21]]|0.639|
|[[:human genes:y:yars2|YARS2]]|0.632|
|[[:human genes:e:ears2|EARS2]]|0.625|
|[[:human genes:l:lars2|LARS2]]|0.622|
|[[:human genes:m:mrps16|MRPS16]]|0.621|
|[[:human genes:m:mrpl23|MRPL23]]|0.616|
|[[:human genes:t:tars2|TARS2]]|0.615|
|[[:human genes:m:mrps34|MRPS34]]|0.615|
|[[:human genes:s:sco2|SCO2]]|0.61|
|[[:human genes:q:qrsl1|QRSL1]]|0.606|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.604|
|[[:human genes:v:vars2|VARS2]]|0.601|
|[[:human genes:m:mars2|MARS2]]|0.598|
|[[:human genes:d:dars2|DARS2]]|0.592|
|[[:human genes:f:fastkd5|FASTKD5]]|0.586|
|[[:human genes:m:mrps25|MRPS25]]|0.583|
|[[:human genes:g:gfm1|GFM1]]|0.581|
|[[:human genes:m:mrpl53|MRPL53]]|0.579|
|[[:human genes:m:mrps5|MRPS5]]|0.574|
|[[:human genes:p:pet112|PET112]]|0.569|
|[[:human genes:m:mtg2|MTG2]]|0.567|
|[[:human genes:s:sars2|SARS2]]|0.562|
|[[:human genes:a:aars2|AARS2]]|0.56|
|[[:human genes:c:coa3|COA3]]|0.559|
|[[:human genes:m:mrpl47|MRPL47]]|0.559|
|[[:human genes:m:mrps26|MRPS26]]|0.559|
|[[:human genes:r:rbfa|RBFA]]|0.555|
|[[:human genes:s:slc25a26|SLC25A26]]|0.555|
|[[:human genes:b:bcs1l|BCS1L]]|0.553|
|[[:human genes:m:mrps18a|MRPS18A]]|0.552|
|[[:human genes:w:wbscr16|WBSCR16]]|0.551|
|[[:human genes:m:mrps9|MRPS9]]|0.551|
|[[:human genes:m:mrps2|MRPS2]]|0.546|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.544|
|[[:human genes:m:mrp63|MRP63]]|0.544|
|[[:human genes:g:gfm2|GFM2]]|0.539|
|[[:human genes:t:trub2|TRUB2]]|0.535|
|[[:human genes:m:mrpl3|MRPL3]]|0.532|
|[[:human genes:r:rpusd3|RPUSD3]]|0.531|
|[[:human genes:m:mrps10|MRPS10]]|0.531|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.529|
|[[:human genes:m:mrps23|MRPS23]]|0.527|
|[[:human genes:p:pnpt1|PNPT1]]|0.527|
|[[:human genes:m:mrpl15|MRPL15]]|0.523|
|[[:human genes:m:mrpl20|MRPL20]]|0.522|
|[[:human genes:c:c10orf2|C10orf2]]|0.516|
|[[:human genes:m:mrps24|MRPS24]]|0.514|
|[[:human genes:m:mrpl42|MRPL42]]|0.513|
|[[:human genes:r:rpusd4|RPUSD4]]|0.513|
|[[:human genes:n:ndufb11|NDUFB11]]|0.512|
|[[:human genes:c:cox7b|COX7B]]|0.511|
|[[:human genes:m:mrpl43|MRPL43]]|0.509|
|[[:human genes:m:mrps33|MRPS33]]|0.506|
|[[:human genes:t:tufm|TUFM]]|0.502|
|[[:human genes:m:mettl17|METTL17]]|0.502|
|[[:human genes:d:dnlz|DNLZ]]|0.5|
|[[:human genes:m:mrps35|MRPS35]]|0.5|
|[[:human genes:m:mrpl45|MRPL45]]|0.498|
|[[:human genes:f:fars2|FARS2]]|0.498|
|[[:human genes:p:pdss1|PDSS1]]|0.497|
|[[:human genes:t:tefm|TEFM]]|0.496|
|[[:human genes:c:cox17|COX17]]|0.495|
|[[:human genes:n:ndufa3|NDUFA3]]|0.491|
|[[:human genes:m:mrps12|MRPS12]]|0.491|
|[[:human genes:m:mrpl12|MRPL12]]|0.491|
|[[:human genes:m:mrps7|MRPS7]]|0.491|
|[[:human genes:f:ftsj2|FTSJ2]]|0.49|
|[[:human genes:g:gatc|GATC]]|0.49|
|[[:human genes:c:cox11|COX11]]|0.488|
|[[:human genes:t:tfam|TFAM]]|0.484|
|[[:human genes:t:tmem242|TMEM242]]|0.48|
|[[:human genes:m:mrpl33|MRPL33]]|0.479|
|[[:human genes:a:atp5a1|ATP5A1]]|0.478|
|[[:human genes:a:atp5b|ATP5B]]|0.478|
|[[:human genes:c:coa6|COA6]]|0.477|
|[[:human genes:u:uqcr10|UQCR10]]|0.477|
|[[:human genes:n:ndufc2|NDUFC2]]|0.476|
|[[:human genes:m:mrps28|MRPS28]]|0.475|
|[[:human genes:p:polrmt|POLRMT]]|0.471|
|[[:human genes:n:ndufv1|NDUFV1]]|0.47|
|[[:human genes:m:mrpl18|MRPL18]]|0.47|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.468|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.467|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.466|
|[[:human genes:a:atp5d|ATP5D]]|0.466|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.466|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.465|
|[[:human genes:n:ndufb5|NDUFB5]]|0.463|
|[[:human genes:a:atp5c1|ATP5C1]]|0.463|
|[[:human genes:c:c12orf65|C12orf65]]|0.462|
|[[:human genes:t:triap1|TRIAP1]]|0.462|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.461|
|[[:human genes:m:mrpl4|MRPL4]]|0.46|
|[[:human genes:p:pgm3|PGM3]]|0.459|
|[[:human genes:m:mrpl39|MRPL39]]|0.454|
|[[:human genes:m:mtg1|MTG1]]|0.454|
|[[:human genes:o:opa1|OPA1]]|0.454|
|[[:human genes:c:coq7|COQ7]]|0.453|
|[[:human genes:p:pet117|PET117]]|0.453|
|[[:human genes:m:mrpl13|MRPL13]]|0.451|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.45|
|[[:human genes:f:fh|FH]]|0.449|
|[[:human genes:c:cox15|COX15]]|0.445|
|[[:human genes:m:mrpl27|MRPL27]]|0.444|
|[[:human genes:t:tfb1m|TFB1M]]|0.444|
|[[:human genes:t:tamm41|TAMM41]]|0.444|
|[[:human genes:a:aifm1|AIFM1]]|0.442|
|[[:human genes:c:cars2|CARS2]]|0.441|
|[[:human genes:e:elac2|ELAC2]]|0.44|
|[[:human genes:c:cox20|COX20]]|0.44|
|[[:human genes:c:cox5a|COX5A]]|0.438|
|[[:human genes:m:malsu1|MALSU1]]|0.437|
|[[:human genes:m:mterfd1|MTERFD1]]|0.437|
|[[:human genes:p:polg2|POLG2]]|0.436|
|[[:human genes:m:mtpap|MTPAP]]|0.436|
|[[:human genes:c:crls1|CRLS1]]|0.436|
|[[:human genes:w:wars2|WARS2]]|0.436|
|[[:human genes:t:trmt61a|TRMT61A]]|0.434|
|[[:human genes:m:mrpl17|MRPL17]]|0.434|
|[[:human genes:m:mrpl44|MRPL44]]|0.433|
|[[:human genes:n:ndufa1|NDUFA1]]|0.431|
|[[:human genes:m:mipep|MIPEP]]|0.431|
|[[:human genes:p:pitrm1|PITRM1]]|0.431|
|[[:human genes:m:mrps22|MRPS22]]|0.431|
|[[:human genes:a:atp5h|ATP5H]]|0.43|
|[[:human genes:m:mrps27|MRPS27]]|0.429|
|[[:human genes:m:mrpl55|MRPL55]]|0.429|
|[[:human genes:m:mrpl52|MRPL52]]|0.428|
|[[:human genes:d:dhrsx|DHRSX]]|0.427|
|[[:human genes:n:ndufa2|NDUFA2]]|0.426|
|[[:human genes:a:atp5f1|ATP5F1]]|0.425|
|[[:human genes:t:tomm22|TOMM22]]|0.425|
|[[:human genes:m:mrpl28|MRPL28]]|0.424|
|[[:human genes:s:slc25a3|SLC25A3]]|0.423|
|[[:human genes:t:tfb2m|TFB2M]]|0.423|
|[[:human genes:t:tomm20|TOMM20]]|0.422|
|[[:human genes:r:rpia|RPIA]]|0.422|
|[[:human genes:m:mterfd2|MTERFD2]]|0.421|
|[[:human genes:n:ndufb9|NDUFB9]]|0.421|
|[[:human genes:m:mrpl36|MRPL36]]|0.418|
|[[:human genes:c:coq5|COQ5]]|0.417|
|[[:human genes:c:coa5|COA5]]|0.416|
|[[:human genes:a:atp5sl|ATP5SL]]|0.416|
|[[:human genes:p:polg|POLG]]|0.414|
|[[:human genes:l:lsm10|LSM10]]|0.414|
|[[:human genes:m:mrpl2|MRPL2]]|0.413|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.41|
|[[:human genes:t:tpk1|TPK1]]|0.41|
|[[:human genes:m:mtif2|MTIF2]]|0.409|
|[[:human genes:s:sco1|SCO1]]|0.409|
|[[:human genes:m:mrpl51|MRPL51]]|0.409|
|[[:human genes:p:ppcs|PPCS]]|0.409|
|[[:human genes:m:mrpl34|MRPL34]]|0.409|
|[[:human genes:c:cox6b1|COX6B1]]|0.407|
|[[:human genes:n:ndufs2|NDUFS2]]|0.407|
|[[:human genes:t:tmem261|TMEM261]]|0.406|
|[[:human genes:i:iba57|IBA57]]|0.405|
|[[:human genes:u:uqcc2|UQCC2]]|0.405|
|[[:human genes:c:c17orf89|C17orf89]]|0.405|
|[[:human genes:c:chchd1|CHCHD1]]|0.404|
|[[:human genes:c:cox19|COX19]]|0.404|
|[[:human genes:n:ndufa10|NDUFA10]]|0.403|
|[[:human genes:m:mrpl11|MRPL11]]|0.403|
|[[:human genes:m:mrpl35|MRPL35]]|0.402|
|[[:human genes:c:coq2|COQ2]]|0.402|
|[[:human genes:m:mrpl22|MRPL22]]|0.402|
|[[:human genes:s:slc25a19|SLC25A19]]|0.402|
|[[:human genes:t:taz|TAZ]]|0.402|
|[[:human genes:m:mrpl37|MRPL37]]|0.401|
|[[:human genes:a:acad9|ACAD9]]|0.4|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 269/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|12/28|
|bone|6/26|
|breast|18/33|
|central nervous system|10/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|4/21|
|liver|10/20|
|lung|27/75|
|lymphocyte|7/16|
|ovary|3/26|
|pancreas|7/24|
|peripheral nervous system|5/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|11/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1293
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HARS2 Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>