HAUS3 [The Human Chemical-Genetic Interaction Map Project]

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======= HAUS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HAUS3
  * **<color #00a2e8>Official Name</color>**: HAUS augmin like complex subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79441|79441]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q68CZ6|Q68CZ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HAUS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HAUS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|HAUS complex|
|intercellular bridge|
|mitotic spindle|
|centrosome cycle|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|spindle assembly|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|microtubule cytoskeleton|
|spindle organization|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|microtubule|
|cilium assembly|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|molecular function|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|mitochondrion|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.97|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.74|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.91|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|4.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nup54|NUP54]]|0.435|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 254/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|7/28|
|bone|15/26|
|breast|15/33|
|central nervous system|26/56|
|cervix|3/4|
|colorectal|2/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|7/21|
|liver|7/20|
|lung|16/75|
|lymphocyte|9/16|
|ovary|11/26|
|pancreas|8/24|
|peripheral nervous system|7/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|14/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|12/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1402
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HAUS3 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>