HBA1 [The Human Chemical-Genetic Interaction Map Project]

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======= HBA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HBA1
  * **<color #00a2e8>Official Name</color>**: hemoglobin subunit alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3039|3039]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P69905|P69905]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HBA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HBA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/141800|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in oxygen transport from the lung to the various peripheral tissues.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Globin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|haptoglobin binding|
|organic acid binding|
|haptoglobin-hemoglobin complex|
|hemoglobin complex|
|oxygen carrier activity|
|oxygen transport|
|endocytic vesicle lumen|
|gas transport|
|hydrogen peroxide catabolic process|
|oxygen binding|
|peroxidase activity|
|hydrogen peroxide metabolic process|
|bicarbonate transport|
|cytosolic small ribosomal subunit|
|antibiotic catabolic process|
|cofactor catabolic process|
|cellular oxidant detoxification|
|cellular detoxification|
|antibiotic metabolic process|
|protein heterooligomerization|
|reactive oxygen species metabolic process|
|response to hydrogen peroxide|
|detoxification|
|iron ion binding|
|blood microparticle|
|heme binding|
|drug catabolic process|
|drug transport|
|response to reactive oxygen species|
|cellular response to toxic substance|
|receptor-mediated endocytosis|
|response to antibiotic|
|response to oxidative stress|
|cofactor metabolic process|
|organic anion transport|
|drug metabolic process|
|response to toxic substance|
|protein complex oligomerization|
|response to inorganic substance|
|endocytosis|
|anion transport|
|import into cell|
|positive regulation of cell death|
|response to drug|
|ion transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|extracellular space|
|regulation of cell death|
|cellular catabolic process|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6203
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HBA1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>