HBB [The Human Chemical-Genetic Interaction Map Project]

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======= HBB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HBB
  * **<color #00a2e8>Official Name</color>**: hemoglobin subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3043|3043]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68871|P68871]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HBB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HBB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/141900|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Globin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hemoglobin alpha binding|
|nitric oxide transport|
|hemoglobin binding|
|haptoglobin binding|
|haptoglobin-hemoglobin complex|
|organic acid binding|
|hemoglobin complex|
|oxygen carrier activity|
|oxygen transport|
|renal absorption|
|endocytic vesicle lumen|
|gas transport|
|hydrogen peroxide catabolic process|
|oxygen binding|
|peroxidase activity|
|hydrogen peroxide metabolic process|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|bicarbonate transport|
|platelet aggregation|
|positive regulation of reactive oxygen species biosynthetic process|
|antibiotic catabolic process|
|tertiary granule lumen|
|regulation of nitric oxide biosynthetic process|
|homotypic cell-cell adhesion|
|cofactor catabolic process|
|regulation of reactive oxygen species biosynthetic process|
|cellular oxidant detoxification|
|positive regulation of reactive oxygen species metabolic process|
|cellular detoxification|
|antibiotic metabolic process|
|protein heterooligomerization|
|renal system process|
|reactive oxygen species metabolic process|
|response to hydrogen peroxide|
|ficolin-1-rich granule lumen|
|detoxification|
|platelet activation|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|blood microparticle|
|heme binding|
|drug catabolic process|
|drug transport|
|vascular process in circulatory system|
|neurotransmitter transport|
|regulation of reactive oxygen species metabolic process|
|regulation of blood pressure|
|response to reactive oxygen species|
|cellular response to toxic substance|
|receptor-mediated endocytosis|
|blood coagulation|
|coagulation|
|hemostasis|
|response to antibiotic|
|regulation of neurotransmitter levels|
|response to oxidative stress|
|blood circulation|
|circulatory system process|
|cofactor metabolic process|
|organic anion transport|
|wound healing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|response to toxic substance|
|leukocyte degranulation|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|response to inorganic substance|
|endocytosis|
|response to wounding|
|anion transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|import into cell|
|positive regulation of cell death|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|secretion by cell|
|response to drug|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|ion transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|extracellular space|
|regulation of cell death|
|cellular catabolic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16604
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HBB Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>