HCK [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= HCK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HCK
  * **<color #00a2e8>Official Name</color>**: HCK proto-oncogene, Src family tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3055|3055]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08631|P08631]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HCK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HCK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|SH3 1|
|Pkinase Tyr|
|SH2|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leukocyte migration involved in immune response|
|respiratory burst after phagocytosis|
|respiratory burst involved in defense response|
|regulation of podosome assembly|
|positive regulation of actin cytoskeleton reorganization|
|respiratory burst|
|regulation of defense response to virus by virus|
|peptidyl-tyrosine autophosphorylation|
|lipopolysaccharide-mediated signaling pathway|
|regulation of actin cytoskeleton reorganization|
|phosphotyrosine residue binding|
|non-membrane spanning protein tyrosine kinase activity|
|extrinsic component of cytoplasmic side of plasma membrane|
|interferon-gamma-mediated signaling pathway|
|caveola|
|actin filament|
|protein tyrosine kinase activity|
|positive regulation of actin filament polymerization|
|transport vesicle|
|integrin-mediated signaling pathway|
|regulation of phagocytosis|
|cell projection|
|mesoderm development|
|positive regulation of protein polymerization|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|regulation of cell shape|
|cellular response to interferon-gamma|
|regulation of actin filament polymerization|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|protein autophosphorylation|
|positive regulation of supramolecular fiber organization|
|cellular response to biotic stimulus|
|regulation of organelle assembly|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|innate immune response-activating signal transduction|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|lysosome|
|activation of innate immune response|
|regulation of actin filament organization|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|phagocytosis|
|signaling receptor binding|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|positive regulation of response to biotic stimulus|
|regulation of cellular component size|
|leukocyte migration|
|regulation of actin filament-based process|
|focal adhesion|
|regulation of DNA-binding transcription factor activity|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of cell morphogenesis|
|inflammatory response|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|regulation of anatomical structure size|
|cellular response to lipid|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|activation of immune response|
|cytokine-mediated signaling pathway|
|response to bacterium|
|viral process|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|response to lipid|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|Golgi apparatus|
|negative regulation of cell death|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell death|
|tissue development|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9377
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HCK Expression in NALM6 Cells: 1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>