HCLS1 [The Human Chemical-Genetic Interaction Map Project]

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======= HCLS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HCLS1
  * **<color #00a2e8>Official Name</color>**: hematopoietic cell-specific Lyn substrate 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3059|3059]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14317|P14317]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HCLS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HCLS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601306|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|SH3 2|
|HS1 rep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|site of polarized growth|
|positive regulation of granulocyte differentiation|
|positive regulation of macrophage differentiation|
|regulation of granulocyte differentiation|
|positive regulation of actin cytoskeleton reorganization|
|regulation of macrophage differentiation|
|actin filament polymerization|
|regulation of actin cytoskeleton reorganization|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|negative regulation of leukocyte apoptotic process|
|actin polymerization or depolymerization|
|cortical actin cytoskeleton|
|regulation of protein import into nucleus|
|positive regulation of myeloid leukocyte differentiation|
|regulation of protein import|
|RNA polymerase II transcription factor binding|
|positive regulation of nucleocytoplasmic transport|
|positive regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of protein localization to nucleus|
|regulation of tyrosine phosphorylation of STAT protein|
|erythrocyte differentiation|
|actin filament|
|regulation of leukocyte apoptotic process|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|protein polymerization|
|positive regulation of receptor signaling pathway via STAT|
|erythrocyte homeostasis|
|positive regulation of myeloid cell differentiation|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of nucleocytoplasmic transport|
|myeloid cell homeostasis|
|regulation of myeloid leukocyte differentiation|
|regulation of protein localization to nucleus|
|regulation of phosphatidylinositol 3-kinase signaling|
|regulation of receptor signaling pathway via JAK-STAT|
|SH3 domain binding|
|regulation of receptor signaling pathway via STAT|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of leukocyte differentiation|
|positive regulation of intracellular protein transport|
|positive regulation of protein kinase B signaling|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|homeostasis of number of cells|
|actin filament binding|
|transcription factor complex|
|positive regulation of intracellular transport|
|regulation of protein kinase B signaling|
|positive regulation of cytoskeleton organization|
|myeloid cell differentiation|
|regulation of protein polymerization|
|regulation of myeloid cell differentiation|
|regulation of intracellular protein transport|
|actin filament organization|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of actin filament organization|
|positive regulation of DNA-binding transcription factor activity|
|protein-containing complex binding|
|actin binding|
|regulation of leukocyte differentiation|
|positive regulation of cellular protein localization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|regulation of cellular component size|
|regulation of actin filament-based process|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|regulation of hemopoiesis|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|hemopoiesis|
|actin filament-based process|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|immune system development|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|cellular protein-containing complex assembly|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|positive regulation of transport|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|response to cytokine|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.7|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.89|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:x:xylt2|XYLT2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2564
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HCLS1 Expression in NALM6 Cells: 5.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>