HCRT [The Human Chemical-Genetic Interaction Map Project]

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======= HCRT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HCRT
  * **<color #00a2e8>Official Name</color>**: hypocretin neuropeptide precursor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3060|3060]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43612|O43612]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HCRT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HCRT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602358|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Orexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 1 hypocretin receptor binding|
|type 2 hypocretin receptor binding|
|negative regulation of transmission of nerve impulse|
|positive regulation of transmission of nerve impulse|
|sleep|
|regulation of transmission of nerve impulse|
|negative regulation of nervous system process|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|neuropeptide hormone activity|
|eating behavior|
|temperature homeostasis|
|negative regulation of potassium ion transport|
|negative regulation of DNA replication|
|rough endoplasmic reticulum|
|positive regulation of nervous system process|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|postsynapse|
|feeding behavior|
|secretory granule|
|regulation of potassium ion transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of cold-induced thermogenesis|
|regulation of postsynaptic membrane potential|
|regulation of neurotransmitter secretion|
|neuropeptide signaling pathway|
|regulation of DNA replication|
|synaptic vesicle|
|positive regulation of calcium ion transport|
|regulation of nervous system process|
|regulation of neurotransmitter transport|
|regulation of cold-induced thermogenesis|
|negative regulation of ion transport|
|response to starvation|
|regulation of calcium ion transport|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|regulation of neurotransmitter levels|
|regulation of metal ion transport|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|response to extracellular stimulus|
|cell junction|
|cellular metal ion homeostasis|
|behavior|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cellular homeostasis|
|regulation of cellular localization|
|positive regulation of transport|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|homeostatic process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9975
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HCRT Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>