HDAC3 [The Human Chemical-Genetic Interaction Map Project]

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======= HDAC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDAC3
  * **<color #00a2e8>Official Name</color>**: histone deacetylase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8841|8841]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15379|O15379]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDAC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDAC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605166|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). {ECO:0000269|PubMed:21444723, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hist deacetyl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NAD-dependent histone deacetylase activity (H3-K14 specific)|
|protein deacetylase activity|
|histone H4 deacetylation|
|cellular response to fluid shear stress|
|negative regulation of myotube differentiation|
|histone H3 deacetylation|
|histone deacetylase activity|
|NF-kappaB binding|
|cyclin binding|
|response to fluid shear stress|
|negative regulation of JNK cascade|
|histone deacetylase complex|
|positive regulation of protein import into nucleus|
|negative regulation of striated muscle cell differentiation|
|positive regulation of TOR signaling|
|positive regulation of protein import|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|histone deacetylation|
|protein deacetylation|
|regulation of protein import into nucleus|
|negative regulation of muscle cell differentiation|
|transcriptional repressor complex|
|regulation of myotube differentiation|
|regulation of protein import|
|protein deacylation|
|macromolecule deacylation|
|circadian regulation of gene expression|
|positive regulation of nucleocytoplasmic transport|
|positive regulation of protein localization to nucleus|
|mitotic spindle|
|positive regulation of cold-induced thermogenesis|
|spindle assembly|
|regulation of striated muscle cell differentiation|
|regulation of TOR signaling|
|regulation of nucleocytoplasmic transport|
|histone deacetylase binding|
|regulation of circadian rhythm|
|positive regulation of protein ubiquitination|
|regulation of protein localization to nucleus|
|positive regulation of protein modification by small protein conjugation or removal|
|circadian rhythm|
|regulation of cold-induced thermogenesis|
|regulation of muscle cell differentiation|
|positive regulation of intracellular protein transport|
|spindle organization|
|negative regulation of MAPK cascade|
|regulation of JNK cascade|
|regulation of protein ubiquitination|
|positive regulation of intracellular transport|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|transcription corepressor activity|
|rhythmic process|
|regulation of protein stability|
|positive regulation of cellular protein localization|
|transcription factor binding|
|enzyme binding|
|regulation of intracellular transport|
|histone modification|
|covalent chromatin modification|
|chromatin binding|
|regulation of lipid metabolic process|
|negative regulation of protein phosphorylation|
|positive regulation of protein transport|
|negative regulation of phosphorylation|
|positive regulation of establishment of protein localization|
|microtubule cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|microtubule-based process|
|chromatin organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|organelle assembly|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|negative regulation of developmental process|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|chromosome organization|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.78|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.71|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.7|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.62|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.54|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.47|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.41|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.35|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.24|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.15|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.15|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.12|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.1|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.06|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.06|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.05|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.03|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.93|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.93|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.93|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.92|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.92|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.87|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.87|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.86|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.84|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.83|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.81|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.78|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.72|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.71|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.83|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.86|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.23|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.7|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ncor1|NCOR1]]|0.61|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 571/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|23/28|
|bone|16/25|
|breast|29/33|
|central nervous system|49/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|12/15|
|kidney|18/21|
|liver|16/20|
|lung|59/75|
|lymphocyte|13/14|
|ovary|20/26|
|pancreas|20/24|
|peripheral nervous system|10/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|7/7|
|thyroid|1/2|
|upper aerodigestive|17/22|
|urinary tract|27/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1392
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDAC3 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>