HDAC6 [The Human Chemical-Genetic Interaction Map Project]

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======= HDAC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDAC6
  * **<color #00a2e8>Official Name</color>**: histone deacetylase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10013|10013]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBN7|Q9UBN7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDAC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDAC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300272|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000250, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:24413532}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hist deacetyl|
|zf-UBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Hsp90 deacetylation|
|polyubiquitinated misfolded protein transport|
|misfolded protein transport|
|polyubiquitinated protein transport|
|positive regulation of chaperone-mediated protein complex assembly|
|tubulin deacetylase activity|
|regulation of chaperone-mediated protein complex assembly|
|polyamine deacetylation|
|tubulin deacetylation|
|acetylspermidine deacetylase activity|
|spermidine deacetylation|
|positive regulation of hydrogen peroxide-mediated programmed cell death|
|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|
|positive regulation of hydrogen peroxide-induced cell death|
|aggresome assembly|
|inclusion body assembly|
|negative regulation of hydrogen peroxide metabolic process|
|positive regulation of response to reactive oxygen species|
|peptidyl-lysine deacetylation|
|negative regulation of cofactor metabolic process|
|positive regulation of mitophagy in response to mitochondrial depolarization|
|collateral sprouting|
|positive regulation of mitophagy|
|regulation of hydrogen peroxide-mediated programmed cell death|
|NAD-dependent histone deacetylase activity (H3-K14 specific)|
|spermidine metabolic process|
|positive regulation of cellular response to drug|
|protein deacetylase activity|
|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|positive regulation of receptor biosynthetic process|
|regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|positive regulation of oxidative stress-induced cell death|
|regulation of mitophagy|
|positive regulation of cellular response to oxidative stress|
|polyamine metabolic process|
|dendritic spine morphogenesis|
|positive regulation of autophagy of mitochondrion|
|response to mitochondrial depolarisation|
|inclusion body|
|positive regulation of response to oxidative stress|
|histone H3 deacetylation|
|regulation of hydrogen peroxide metabolic process|
|dynein complex binding|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|regulation of hydrogen peroxide-induced cell death|
|regulation of receptor biosynthetic process|
|negative regulation of oxidoreductase activity|
|cellular response to misfolded protein|
|positive regulation of protein oligomerization|
|dynein complex|
|negative regulation of microtubule depolymerization|
|response to misfolded protein|
|regulation of androgen receptor signaling pathway|
|misfolded protein binding|
|histone deacetylase activity|
|protein quality control for misfolded or incompletely synthesized proteins|
|dendritic spine development|
|regulation of microtubule depolymerization|
|polyubiquitin modification-dependent protein binding|
|regulation of microtubule-based movement|
|positive regulation of response to drug|
|dendritic spine organization|
|microtubule associated complex|
|multivesicular body|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|histone deacetylase complex|
|regulation of cofactor metabolic process|
|negative regulation of microtubule polymerization or depolymerization|
|beta-tubulin binding|
|alpha-tubulin binding|
|neuron projection organization|
|Hsp90 protein binding|
|regulation of autophagy of mitochondrion|
|cell leading edge|
|aggresome|
|regulation of protein oligomerization|
|lysosome localization|
|tau protein binding|
|mitochondrion localization|
|histone deacetylation|
|protein deacetylation|
|cytoplasmic microtubule|
|negative regulation of reactive oxygen species metabolic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|dendrite morphogenesis|
|protein deacylation|
|negative regulation of protein depolymerization|
|macromolecule deacylation|
|regulation of oxidative stress-induced cell death|
|amine metabolic process|
|positive regulation of macroautophagy|
|cellular response to hydrogen peroxide|
|negative regulation of protein complex disassembly|
|regulation of cellular response to oxidative stress|
|caveola|
|regulation of intracellular steroid hormone receptor signaling pathway|
|ubiquitin binding|
|regulation of microtubule polymerization or depolymerization|
|beta-catenin binding|
|regulation of protein depolymerization|
|regulation of response to oxidative stress|
|postsynapse organization|
|developmental cell growth|
|cell growth|
|regulation of oxidoreductase activity|
|regulation of response to drug|
|dendrite development|
|positive regulation of peptidyl-serine phosphorylation|
|histone deacetylase binding|
|regulation of protein complex disassembly|
|developmental growth involved in morphogenesis|
|positive regulation of mitochondrion organization|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|positive regulation of autophagy|
|regulation of fat cell differentiation|
|cellular response to reactive oxygen species|
|negative regulation of supramolecular fiber organization|
|perikaryon|
|regulation of peptidyl-serine phosphorylation|
|negative regulation of cytoskeleton organization|
|positive regulation of epithelial cell migration|
|cellular response to topologically incorrect protein|
|regulation of signaling receptor activity|
|regulation of macroautophagy|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|response to topologically incorrect protein|
|regulation of microtubule cytoskeleton organization|
|ammonium ion metabolic process|
|response to reactive oxygen species|
|cellular response to toxic substance|
|regulation of epithelial cell migration|
|regulation of microtubule-based process|
|regulation of gene expression, epigenetic|
|microtubule binding|
|cellular response to oxidative stress|
|protein-containing complex disassembly|
|positive regulation of protein complex assembly|
|process utilizing autophagic mechanism|
|autophagy|
|actin binding|
|synapse organization|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|axon|
|protein polyubiquitination|
|response to antibiotic|
|peptidyl-lysine modification|
|microtubule|
|regulation of autophagy|
|cilium assembly|
|enzyme binding|
|regulation of supramolecular fiber organization|
|negative regulation of proteolysis|
|positive regulation of cellular catabolic process|
|histone modification|
|cilium organization|
|axonogenesis|
|negative regulation of organelle organization|
|covalent chromatin modification|
|response to oxidative stress|
|developmental growth|
|growth|
|cellular component disassembly|
|cellular response to drug|
|axon development|
|dendrite|
|positive regulation of catabolic process|
|cell morphogenesis involved in neuron differentiation|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|cell projection assembly|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|positive regulation of programmed cell death|
|neuron projection development|
|protein catabolic process|
|protein ubiquitination|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|chromatin organization|
|negative regulation of cellular component organization|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of establishment of protein localization|
|organelle assembly|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|zinc ion binding|
|regulation of cell migration|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of cellular component movement|
|intracellular protein transport|
|regulation of catabolic process|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|peptide transport|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.71|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.76|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4381
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDAC6 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>