HDAC8 [The Human Chemical-Genetic Interaction Map Project]

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======= HDAC8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDAC8
  * **<color #00a2e8>Official Name</color>**: histone deacetylase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55869|55869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BY41|Q9BY41]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDAC8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDAC8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300269|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hist deacetyl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cohesin loading|
|regulation of protein localization to chromatin|
|NAD-dependent histone deacetylase activity (H3-K14 specific)|
|histone H4 deacetylation|
|histone H3 deacetylation|
|regulation of sister chromatid cohesion|
|histone deacetylase activity|
|nuclear chromosome|
|histone deacetylase complex|
|Hsp90 protein binding|
|Hsp70 protein binding|
|sister chromatid cohesion|
|histone deacetylation|
|protein deacetylation|
|protein deacylation|
|macromolecule deacylation|
|negative regulation of protein ubiquitination|
|regulation of sister chromatid segregation|
|regulation of telomere maintenance|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of chromosome segregation|
|regulation of DNA binding|
|sister chromatid segregation|
|chromatin assembly or disassembly|
|regulation of protein ubiquitination|
|nuclear chromosome segregation|
|regulation of protein modification by small protein conjugation or removal|
|chromosome segregation|
|regulation of protein stability|
|transcription factor binding|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|regulation of cellular protein localization|
|negative regulation of protein modification process|
|chromatin organization|
|regulation of cell cycle process|
|negative regulation of transcription by RNA polymerase II|
|regulation of cellular localization|
|cell cycle process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.16|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.09|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.83|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.79|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.71|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.85|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.93|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13|MED13]]|0.573|
|[[:human genes:m:med13l|MED13L]]|0.505|
|[[:human genes:t:taf6l|TAF6L]]|0.5|
|[[:human genes:d:dek|DEK]]|0.499|
|[[:human genes:s:supt7l|SUPT7L]]|0.481|
|[[:human genes:f:fli1|FLI1]]|0.47|
|[[:human genes:c:ccnc|CCNC]]|0.447|
|[[:human genes:z:zc3h18|ZC3H18]]|0.437|
|[[:human genes:p:prr12|PRR12]]|0.432|
|[[:human genes:t:tada3|TADA3]]|0.426|
|[[:human genes:t:taf5l|TAF5L]]|0.417|
|[[:human genes:c:clk3|CLK3]]|0.416|
|[[:human genes:e:ehmt2|EHMT2]]|0.415|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.413|
|[[:human genes:m:med23|MED23]]|0.412|
|[[:human genes:s:sik3|SIK3]]|0.403|
|[[:human genes:b:btaf1|BTAF1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|1/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|1/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1704
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDAC8 Expression in NALM6 Cells: 3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>