HERC1 [The Human Chemical-Genetic Interaction Map Project]

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======= HERC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HERC1
  * **<color #00a2e8>Official Name</color>**: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8925|8925]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15751|Q15751]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HERC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HERC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605109|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPRY|
|RCC1|
|HECT|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellar Purkinje cell differentiation|
|cerebellar Purkinje cell layer formation|
|cerebellar Purkinje cell layer morphogenesis|
|cell differentiation in hindbrain|
|ARF guanyl-nucleotide exchange factor activity|
|cerebellar cortex formation|
|cerebellar Purkinje cell layer development|
|cerebellar cortex morphogenesis|
|cerebellum morphogenesis|
|hindbrain morphogenesis|
|cerebellar cortex development|
|neuromuscular process controlling balance|
|negative regulation of autophagy|
|cerebellum development|
|neuromuscular process|
|metencephalon development|
|hindbrain development|
|central nervous system neuron differentiation|
|ubiquitin-protein transferase activity|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|regulation of autophagy|
|neuron projection development|
|protein ubiquitination|
|brain development|
|protein modification by small protein conjugation|
|head development|
|neuron development|
|regulation of cellular catabolic process|
|anatomical structure formation involved in morphogenesis|
|central nervous system development|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|nervous system process|
|generation of neurons|
|neurogenesis|
|cell development|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.75|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.13|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3924
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HERC1 Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>