HERPUD1 [The Human Chemical-Genetic Interaction Map Project]

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======= HERPUD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HERPUD1
  * **<color #00a2e8>Official Name</color>**: homocysteine inducible ER protein with ubiquitin like domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9709|9709]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15011|Q15011]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HERPUD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HERPUD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982). {ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:18307982}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ubiquitin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Lewy body core|
|protein binding, bridging involved in substrate recognition for ubiquitination|
|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|
|regulation of ER-associated ubiquitin-dependent protein catabolic process|
|PERK-mediated unfolded protein response|
|positive regulation of ERAD pathway|
|endoplasmic reticulum to cytosol transport|
|retrograde protein transport, ER to cytosol|
|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|endoplasmic reticulum calcium ion homeostasis|
|calcium channel complex|
|protein exit from endoplasmic reticulum|
|regulation of ERAD pathway|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|ER-nucleus signaling pathway|
|positive regulation of response to endoplasmic reticulum stress|
|negative regulation of response to endoplasmic reticulum stress|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of response to endoplasmic reticulum stress|
|ERAD pathway|
|negative regulation of cysteine-type endopeptidase activity|
|negative regulation of intrinsic apoptotic signaling pathway|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|endoplasmic reticulum unfolded protein response|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|ion channel binding|
|cellular response to unfolded protein|
|positive regulation of cellular protein catabolic process|
|cellular response to topologically incorrect protein|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of intrinsic apoptotic signaling pathway|
|response to unfolded protein|
|regulation of proteasomal protein catabolic process|
|response to topologically incorrect protein|
|regulation of protein ubiquitination|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of apoptotic signaling pathway|
|regulation of protein modification by small protein conjugation or removal|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|regulation of cellular protein catabolic process|
|negative regulation of peptidase activity|
|response to endoplasmic reticulum stress|
|proteasomal protein catabolic process|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|positive regulation of catabolic process|
|cellular calcium ion homeostasis|
|regulation of peptidase activity|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|negative regulation of intracellular signal transduction|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cellular metal ion homeostasis|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|protein catabolic process|
|protein ubiquitination|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|molecular function|
|protein modification by small protein conjugation|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cell death|
|intracellular protein transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.13|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.71|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.71|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.72|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:manf|MANF]]|0.456|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1960
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HERPUD1 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>