HEYL [The Human Chemical-Genetic Interaction Map Project]

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======= HEYL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HEYL
  * **<color #00a2e8>Official Name</color>**: hes related family bHLH transcription factor with YRPW motif like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26508|26508]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQ87|Q9NQ87]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HEYL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HEYL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609034|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000250, ECO:0000269|PubMed:15485867}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
|Hairy orange|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|AF-1 domain binding|
|proximal tubule development|
|Notch signaling involved in heart development|
|epithelial to mesenchymal transition involved in endocardial cushion formation|
|negative regulation of androgen receptor signaling pathway|
|pulmonary valve morphogenesis|
|positive regulation of transcription of Notch receptor target|
|endocardial cushion formation|
|pulmonary valve development|
|cell surface receptor signaling pathway involved in heart development|
|atrioventricular valve morphogenesis|
|regulation of androgen receptor signaling pathway|
|atrioventricular valve development|
|aortic valve morphogenesis|
|cardiac epithelial to mesenchymal transition|
|aortic valve development|
|endocardial cushion morphogenesis|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|semi-lunar valve development|
|ventricular septum morphogenesis|
|endocardial cushion development|
|skeletal muscle cell differentiation|
|mesenchyme morphogenesis|
|glomerulus development|
|heart valve morphogenesis|
|heart valve development|
|epithelial to mesenchymal transition|
|ventricular septum development|
|cardiac ventricle morphogenesis|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|regulation of intracellular steroid hormone receptor signaling pathway|
|nephron tubule development|
|renal tubule development|
|mesenchymal cell development|
|nephron epithelium development|
|cellular response to BMP stimulus|
|response to BMP|
|cardiac septum development|
|skeletal muscle tissue development|
|nephron development|
|Notch signaling pathway|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|kidney epithelium development|
|skeletal muscle organ development|
|mesenchymal cell differentiation|
|negative regulation of DNA-binding transcription factor activity|
|cardiac chamber development|
|anterior/posterior pattern specification|
|mesenchyme development|
|transcription corepressor activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|heart morphogenesis|
|kidney development|
|renal system development|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|urogenital system development|
|regionalization|
|transcription factor binding|
|positive regulation of neuron differentiation|
|regulation of DNA-binding transcription factor activity|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of neurogenesis|
|muscle structure development|
|protein heterodimerization activity|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|tissue morphogenesis|
|regulation of neuron differentiation|
|DNA-binding transcription factor activity|
|regulation of neurogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|epithelium development|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17575
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HEYL Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>