HGS [The Human Chemical-Genetic Interaction Map Project]

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======= HGS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HGS
  * **<color #00a2e8>Official Name</color>**: hepatocyte growth factor-regulated tyrosine kinase substrate
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9146|9146]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14964|O14964]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HGS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HGS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604375|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VHS|
|Hrs helical|
|FYVE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ESCRT-0 complex|
|multivesicular body membrane|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|negative regulation of vascular endothelial growth factor receptor signaling pathway|
|positive regulation of exosomal secretion|
|regulation of exosomal secretion|
|negative regulation of receptor signaling pathway via JAK-STAT|
|protein targeting to lysosome|
|negative regulation of receptor signaling pathway via STAT|
|ubiquitin-like protein ligase binding|
|regulation of platelet-derived growth factor receptor signaling pathway|
|multivesicular body assembly|
|multivesicular body organization|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|protein targeting to vacuole|
|protein localization to lysosome|
|negative regulation of epidermal growth factor receptor signaling pathway|
|establishment of protein localization to vacuole|
|negative regulation of ERBB signaling pathway|
|protein localization to vacuole|
|endosome organization|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of exocytosis|
|regulation of ERBB signaling pathway|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|lysosomal transport|
|negative regulation of vasculature development|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|vacuolar transport|
|membrane invagination|
|negative regulation of cellular response to growth factor stimulus|
|early endosome membrane|
|macroautophagy|
|regulation of exocytosis|
|endosomal transport|
|protein domain specific binding|
|lysosome|
|early endosome|
|process utilizing autophagic mechanism|
|autophagy|
|endosome|
|regulation of cellular response to growth factor stimulus|
|protein deubiquitination|
|regulation of angiogenesis|
|protein modification by small protein removal|
|vesicle organization|
|regulation of vasculature development|
|regulation of MAP kinase activity|
|protein targeting|
|regulation of protein catabolic process|
|positive regulation of secretion by cell|
|endomembrane system organization|
|establishment of protein localization to organelle|
|positive regulation of secretion|
|protein localization to membrane|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|regulation of vesicle-mediated transport|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|protein localization to organelle|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|organelle assembly|
|regulation of protein kinase activity|
|regulation of secretion|
|membrane organization|
|regulation of kinase activity|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.59|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.16|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.03|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.99|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.98|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.97|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.91|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.87|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.86|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.81|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.8|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.79|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.79|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.74|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:actr3|ACTR3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 62/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|7/28|
|bone|2/26|
|breast|6/33|
|central nervous system|4/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|1/21|
|liver|2/20|
|lung|5/75|
|lymphocyte|3/16|
|ovary|4/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1913
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HGS Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>