HIGD2A [The Human Chemical-Genetic Interaction Map Project]

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======= HIGD2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIGD2A
  * **<color #00a2e8>Official Name</color>**: HIG1 hypoxia inducible domain family member 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=192286|192286]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BW72|Q9BW72]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIGD2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIGD2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620788|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HIG 1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respirasome|
|mitochondrial inner membrane|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|oxidation-reduction process|
|negative regulation of cell death|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.534|
|[[:human genes:q:qrsl1|QRSL1]]|0.527|
|[[:human genes:s:sco2|SCO2]]|0.512|
|[[:human genes:d:dap3|DAP3]]|0.505|
|[[:human genes:n:nars2|NARS2]]|0.502|
|[[:human genes:m:mrpl21|MRPL21]]|0.502|
|[[:human genes:m:mrps6|MRPS6]]|0.502|
|[[:human genes:y:yars2|YARS2]]|0.499|
|[[:human genes:m:mrps25|MRPS25]]|0.492|
|[[:human genes:m:mrpl47|MRPL47]]|0.492|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.491|
|[[:human genes:m:mrps16|MRPS16]]|0.49|
|[[:human genes:p:pet117|PET117]]|0.489|
|[[:human genes:c:coa3|COA3]]|0.481|
|[[:human genes:m:mrps21|MRPS21]]|0.472|
|[[:human genes:c:coa6|COA6]]|0.471|
|[[:human genes:m:mrps26|MRPS26]]|0.465|
|[[:human genes:m:mrps12|MRPS12]]|0.463|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.459|
|[[:human genes:f:ftsj2|FTSJ2]]|0.457|
|[[:human genes:m:mrpl23|MRPL23]]|0.457|
|[[:human genes:r:rbfa|RBFA]]|0.453|
|[[:human genes:w:wbscr16|WBSCR16]]|0.452|
|[[:human genes:m:mrp63|MRP63]]|0.452|
|[[:human genes:c:cox16|COX16]]|0.449|
|[[:human genes:v:vars2|VARS2]]|0.448|
|[[:human genes:g:gfm1|GFM1]]|0.448|
|[[:human genes:r:rpusd4|RPUSD4]]|0.447|
|[[:human genes:m:mrpl33|MRPL33]]|0.445|
|[[:human genes:f:fars2|FARS2]]|0.444|
|[[:human genes:e:ears2|EARS2]]|0.442|
|[[:human genes:c:coq5|COQ5]]|0.442|
|[[:human genes:m:mrpl20|MRPL20]]|0.441|
|[[:human genes:c:cox7b|COX7B]]|0.441|
|[[:human genes:l:lrpprc|LRPPRC]]|0.44|
|[[:human genes:b:bcs1l|BCS1L]]|0.439|
|[[:human genes:m:mrps9|MRPS9]]|0.438|
|[[:human genes:m:mrps34|MRPS34]]|0.438|
|[[:human genes:m:mrps14|MRPS14]]|0.438|
|[[:human genes:s:sars2|SARS2]]|0.436|
|[[:human genes:m:mtg1|MTG1]]|0.436|
|[[:human genes:c:coa5|COA5]]|0.435|
|[[:human genes:m:mrpl22|MRPL22]]|0.435|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.434|
|[[:human genes:n:ndufa3|NDUFA3]]|0.434|
|[[:human genes:p:pet112|PET112]]|0.431|
|[[:human genes:c:c12orf65|C12orf65]]|0.429|
|[[:human genes:m:mrps11|MRPS11]]|0.429|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.429|
|[[:human genes:d:dars2|DARS2]]|0.429|
|[[:human genes:l:lars2|LARS2]]|0.425|
|[[:human genes:m:mrpl53|MRPL53]]|0.425|
|[[:human genes:r:rpusd3|RPUSD3]]|0.423|
|[[:human genes:m:malsu1|MALSU1]]|0.421|
|[[:human genes:m:mars2|MARS2]]|0.42|
|[[:human genes:p:pars2|PARS2]]|0.418|
|[[:human genes:a:atp5c1|ATP5C1]]|0.418|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.417|
|[[:human genes:m:mrps5|MRPS5]]|0.416|
|[[:human genes:f:fastkd5|FASTKD5]]|0.416|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.416|
|[[:human genes:n:ndufa1|NDUFA1]]|0.415|
|[[:human genes:p:pnpt1|PNPT1]]|0.413|
|[[:human genes:c:cox6b1|COX6B1]]|0.413|
|[[:human genes:m:mrpl1|MRPL1]]|0.412|
|[[:human genes:m:mrpl45|MRPL45]]|0.408|
|[[:human genes:a:aifm1|AIFM1]]|0.407|
|[[:human genes:t:tars2|TARS2]]|0.406|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.406|
|[[:human genes:c:cox15|COX15]]|0.404|
|[[:human genes:m:mrps18a|MRPS18A]]|0.403|
|[[:human genes:a:aars2|AARS2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2833
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIGD2A Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>