HIPK2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= HIPK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIPK2
  * **<color #00a2e8>Official Name</color>**: homeodomain interacting protein kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28996|28996]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2X6|Q9H2X6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIPK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIPK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606868|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO- protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation- mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lens induction in camera-type eye|
|voluntary musculoskeletal movement|
|embryonic retina morphogenesis in camera-type eye|
|PML body organization|
|iris morphogenesis|
|virion binding|
|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|DNA damage response, signal transduction resulting in transcription|
|nuclear body organization|
|lens morphogenesis in camera-type eye|
|retina layer formation|
|embryonic camera-type eye morphogenesis|
|developmental induction|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|adult walking behavior|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|walking behavior|
|modulation by virus of host morphology or physiology|
|embryonic eye morphogenesis|
|embryonic camera-type eye development|
|modification by symbiont of host morphology or physiology|
|musculoskeletal movement|
|multicellular organismal movement|
|negative regulation of ubiquitin-dependent protein catabolic process|
|retina morphogenesis in camera-type eye|
|negative regulation of BMP signaling pathway|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|SMAD binding|
|RNA polymerase II activating transcription factor binding|
|SMAD protein signal transduction|
|positive regulation of DNA binding|
|neural retina development|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|RNA polymerase II transcription factor complex|
|smoothened signaling pathway|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|lens development in camera-type eye|
|adult locomotory behavior|
|DNA damage response, signal transduction by p53 class mediator|
|erythrocyte differentiation|
|peptidyl-threonine phosphorylation|
|negative regulation of cellular protein catabolic process|
|protein tyrosine kinase activity|
|regulation of BMP signaling pathway|
|erythrocyte homeostasis|
|peptidyl-threonine modification|
|positive regulation of protein binding|
|PML body|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|signal transduction in response to DNA damage|
|myeloid cell homeostasis|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|camera-type eye morphogenesis|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|signal transduction by p53 class mediator|
|regulation of DNA binding|
|negative regulation of protein catabolic process|
|nucleus organization|
|positive regulation of JNK cascade|
|retina development in camera-type eye|
|adult behavior|
|negative regulation of neuron apoptotic process|
|negative regulation of cellular response to growth factor stimulus|
|eye morphogenesis|
|intrinsic apoptotic signaling pathway|
|regulation of ubiquitin-dependent protein catabolic process|
|cellular response to transforming growth factor beta stimulus|
|modification of morphology or physiology of other organism|
|interaction with host|
|response to transforming growth factor beta|
|positive regulation of angiogenesis|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|peptidyl-serine phosphorylation|
|positive regulation of binding|
|regulation of signal transduction by p53 class mediator|
|positive regulation of vasculature development|
|regulation of JNK cascade|
|cellular response to hypoxia|
|locomotory behavior|
|cellular response to decreased oxygen levels|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|peptidyl-serine modification|
|homeostasis of number of cells|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|cellular response to oxygen levels|
|regulation of proteolysis involved in cellular protein catabolic process|
|anterior/posterior pattern specification|
|regulation of protein binding|
|myeloid cell differentiation|
|regulation of stress-activated MAPK cascade|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stress-activated protein kinase signaling cascade|
|protein kinase activity|
|transcription corepressor activity|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|sensory organ morphogenesis|
|positive regulation of DNA-binding transcription factor activity|
|regulation of cellular response to growth factor stimulus|
|nuclear body|
|apoptotic signaling pathway|
|transcription coactivator activity|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|negative regulation of catabolic process|
|regulation of neuron death|
|camera-type eye development|
|regulation of vasculature development|
|regionalization|
|response to hypoxia|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|eye development|
|visual system development|
|protein serine/threonine kinase activity|
|sensory system development|
|regulation of binding|
|response to oxygen levels|
|regulation of protein catabolic process|
|regulation of DNA-binding transcription factor activity|
|embryonic organ development|
|pattern specification process|
|cellular response to growth factor stimulus|
|response to growth factor|
|positive regulation of MAPK cascade|
|sensory organ development|
|hemopoiesis|
|embryonic morphogenesis|
|behavior|
|hematopoietic or lymphoid organ development|
|immune system development|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|animal organ morphogenesis|
|protein phosphorylation|
|embryo development|
|regulation of catabolic process|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell death|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14527
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIPK2 Expression in NALM6 Cells: 6.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>