HIST1H2BJ [The Human Chemical-Genetic Interaction Map Project]

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======= HIST1H2BJ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H2BC11
  * **<color #00a2e8>Official Name</color>**: H2B clustered histone 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8970|8970]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06899|P06899]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST1H2BJ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST1H2BJ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615044|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
|CBFD NFYB HMF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|innate immune response in mucosa|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|mucosal immune response|
|organ or tissue specific immune response|
|lipopolysaccharide binding|
|antibacterial humoral response|
|disruption of cells of other organism|
|killing of cells of other organism|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of cytokine-mediated signaling pathway|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|negative regulation of response to cytokine stimulus|
|nucleosome|
|defense response to Gram-negative bacterium|
|cell killing|
|defense response to Gram-positive bacterium|
|antimicrobial humoral response|
|nucleosome assembly|
|chromatin assembly|
|modification of morphology or physiology of other organism|
|chromatin assembly or disassembly|
|nucleosome organization|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|DNA conformation change|
|defense response to bacterium|
|humoral immune response|
|protein heterodimerization activity|
|protein ubiquitination|
|response to bacterium|
|chromatin organization|
|innate immune response|
|protein modification by small protein conjugation|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|defense response to other organism|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|DNA binding|
|protein-containing complex assembly|
|extracellular space|
|negative regulation of response to stimulus|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 638/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|27/28|
|bone|21/26|
|breast|29/33|
|central nervous system|48/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|18/21|
|liver|17/20|
|lung|69/75|
|lymphocyte|10/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|26/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4474
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST1H2BJ Expression in NALM6 Cells: -1.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>