HIST1H3E [The Human Chemical-Genetic Interaction Map Project]

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======= HIST1H3E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H3C6
  * **<color #00a2e8>Official Name</color>**: H3 clustered histone 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8353|8353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68431|P68431]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST1H3E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST1H3E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602813|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.2|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.19|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.08|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.06|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.85|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.74|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.7|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.74|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.81|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.05|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.15|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.468|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8809
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST1H3E Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>