HIST1H4B [The Human Chemical-Genetic Interaction Map Project]

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======= HIST1H4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H4C2
  * **<color #00a2e8>Official Name</color>**: H4 clustered histone 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8366|8366]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62805|P62805]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST1H4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST1H4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602829|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.73|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:orc1|ORC1]]|0.5|
|[[:human genes:o:orc6|ORC6]]|0.493|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.49|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.49|
|[[:human genes:c:c14orf93|C14orf93]]|0.484|
|[[:human genes:v:vasn|VASN]]|0.476|
|[[:human genes:s:slc4a1|SLC4A1]]|0.471|
|[[:human genes:c:chd4|CHD4]]|0.463|
|[[:human genes:t:tceb3c|TCEB3C]]|0.457|
|[[:human genes:s:supt6h|SUPT6H]]|0.454|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.45|
|[[:human genes:m:myt1l|MYT1L]]|0.449|
|[[:human genes:o:or10g3|OR10G3]]|0.443|
|[[:human genes:r:rrm1|RRM1]]|0.438|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.437|
|[[:human genes:n:npipb5|NPIPB5]]|0.436|
|[[:human genes:a:aamp|AAMP]]|0.435|
|[[:human genes:c:copg1|COPG1]]|0.435|
|[[:human genes:p:paf1|PAF1]]|0.429|
|[[:human genes:c:cope|COPE]]|0.426|
|[[:human genes:p:pigs|PIGS]]|0.424|
|[[:human genes:r:rps19|RPS19]]|0.423|
|[[:human genes:p:psmb4|PSMB4]]|0.423|
|[[:human genes:t:ticrr|TICRR]]|0.421|
|[[:human genes:h:hap1|HAP1]]|0.421|
|[[:human genes:c:cbwd5|CBWD5]]|0.42|
|[[:human genes:p:pan3|PAN3]]|0.42|
|[[:human genes:g:golga8o|GOLGA8O]]|0.42|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.419|
|[[:human genes:a:atxn1|ATXN1]]|0.419|
|[[:human genes:c:cbwd3|CBWD3]]|0.416|
|[[:human genes:k:krt78|KRT78]]|0.413|
|[[:human genes:d:disp2|DISP2]]|0.411|
|[[:human genes:c:chaf1a|CHAF1A]]|0.407|
|[[:human genes:p:polr2j3|POLR2J3]]|0.406|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.402|
|[[:human genes:n:nol10|NOL10]]|0.402|
|[[:human genes:k:kctd17|KCTD17]]|0.402|
|[[:human genes:h:hist2h3d|HIST2H3D]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1834
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST1H4B Expression in NALM6 Cells: -1.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>