HIST2H2AC [The Human Chemical-Genetic Interaction Map Project]

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======= HIST2H2AC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H2AC20
  * **<color #00a2e8>Official Name</color>**: H2A clustered histone 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8338|8338]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16777|Q16777]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST2H2AC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST2H2AC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602797|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleosome|
|nuclear chromatin|
|protein heterodimerization activity|
|chromatin organization|
|molecular function|
|chromosome organization|
|DNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.11|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.9|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.81|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.8|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 93/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|12/28|
|bone|6/26|
|breast|5/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|1/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3857
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST2H2AC Expression in NALM6 Cells: 0.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>