HIST2H3A [The Human Chemical-Genetic Interaction Map Project]

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======= HIST2H3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H3C15
  * **<color #00a2e8>Official Name</color>**: H3 clustered histone 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=333932|333932]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q71DI3|Q71DI3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST2H3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST2H3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromatin silencing at rDNA|
|interleukin-7-mediated signaling pathway|
|response to interleukin-7|
|cellular response to interleukin-7|
|nucleosomal DNA binding|
|regulation of megakaryocyte differentiation|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|nucleosome|
|chromatin organization involved in regulation of transcription|
|negative regulation of gene expression, epigenetic|
|regulation of gene silencing by miRNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|nucleosome assembly|
|regulation of gene silencing|
|chromatin assembly|
|gene silencing|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|regulation of myeloid cell differentiation|
|regulation of gene expression, epigenetic|
|protein-DNA complex subunit organization|
|blood coagulation|
|coagulation|
|hemostasis|
|DNA conformation change|
|regulation of hemopoiesis|
|wound healing|
|protein heterodimerization activity|
|regulation of body fluid levels|
|response to wounding|
|cytokine-mediated signaling pathway|
|chromatin organization|
|cellular protein-containing complex assembly|
|cellular response to cytokine stimulus|
|chromosome organization|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of immune system process|
|negative regulation of gene expression|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.574|
|[[:human genes:s:sf3a1|SF3A1]]|0.543|
|[[:human genes:p:psmb4|PSMB4]]|0.536|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.523|
|[[:human genes:i:igfn1|IGFN1]]|0.513|
|[[:human genes:c:chd4|CHD4]]|0.512|
|[[:human genes:n:npipb5|NPIPB5]]|0.51|
|[[:human genes:p:pola1|POLA1]]|0.506|
|[[:human genes:t:tceb3c|TCEB3C]]|0.503|
|[[:human genes:c:copg1|COPG1]]|0.503|
|[[:human genes:p:paf1|PAF1]]|0.501|
|[[:human genes:u:upf1|UPF1]]|0.5|
|[[:human genes:c:c14orf93|C14orf93]]|0.5|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.499|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.499|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.498|
|[[:human genes:p:pola2|POLA2]]|0.498|
|[[:human genes:r:rps2|RPS2]]|0.497|
|[[:human genes:u:uqcrh|UQCRH]]|0.492|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.49|
|[[:human genes:m:mt1e|MT1E]]|0.488|
|[[:human genes:p:pan3|PAN3]]|0.487|
|[[:human genes:s:slc4a1|SLC4A1]]|0.483|
|[[:human genes:p:pwp2|PWP2]]|0.483|
|[[:human genes:v:vasn|VASN]]|0.483|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.483|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.482|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.482|
|[[:human genes:o:orc1|ORC1]]|0.482|
|[[:human genes:h:hap1|HAP1]]|0.482|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.481|
|[[:human genes:c:cope|COPE]]|0.477|
|[[:human genes:p:psmd3|PSMD3]]|0.476|
|[[:human genes:s:sec13|SEC13]]|0.476|
|[[:human genes:u:usp35|USP35]]|0.475|
|[[:human genes:m:med17|MED17]]|0.474|
|[[:human genes:p:psap|PSAP]]|0.473|
|[[:human genes:p:polr2f|POLR2F]]|0.472|
|[[:human genes:r:rpl35|RPL35]]|0.471|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.469|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.468|
|[[:human genes:r:rbbp5|RBBP5]]|0.466|
|[[:human genes:r:rps9|RPS9]]|0.465|
|[[:human genes:k:kctd17|KCTD17]]|0.463|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.462|
|[[:human genes:g:golga8o|GOLGA8O]]|0.462|
|[[:human genes:r:rrp7a|RRP7A]]|0.46|
|[[:human genes:p:psmb2|PSMB2]]|0.459|
|[[:human genes:f:fam160a1|FAM160A1]]|0.457|
|[[:human genes:s:snrpa1|SNRPA1]]|0.456|
|[[:human genes:n:ncapg|NCAPG]]|0.455|
|[[:human genes:b:bysl|BYSL]]|0.455|
|[[:human genes:i:incenp|INCENP]]|0.455|
|[[:human genes:d:disp2|DISP2]]|0.454|
|[[:human genes:r:rps19|RPS19]]|0.453|
|[[:human genes:c:cbwd5|CBWD5]]|0.453|
|[[:human genes:h:hinfp|HINFP]]|0.451|
|[[:human genes:c:cbwd3|CBWD3]]|0.451|
|[[:human genes:s:sfpq|SFPQ]]|0.451|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.45|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.45|
|[[:human genes:p:pole|POLE]]|0.447|
|[[:human genes:s:slc38a7|SLC38A7]]|0.446|
|[[:human genes:o:orc6|ORC6]]|0.446|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.443|
|[[:human genes:u:utp3|UTP3]]|0.443|
|[[:human genes:r:rps5|RPS5]]|0.442|
|[[:human genes:w:wdr75|WDR75]]|0.441|
|[[:human genes:c:cgb2|CGB2]]|0.439|
|[[:human genes:n:nup160|NUP160]]|0.439|
|[[:human genes:c:cdc73|CDC73]]|0.436|
|[[:human genes:t:tspy8|TSPY8]]|0.435|
|[[:human genes:r:rps20|RPS20]]|0.435|
|[[:human genes:n:npipb8|NPIPB8]]|0.435|
|[[:human genes:n:nfatc4|NFATC4]]|0.435|
|[[:human genes:s:slc6a17|SLC6A17]]|0.434|
|[[:human genes:c:ccna2|CCNA2]]|0.431|
|[[:human genes:t:trim52|TRIM52]]|0.431|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.431|
|[[:human genes:p:psmd1|PSMD1]]|0.431|
|[[:human genes:c:chaf1a|CHAF1A]]|0.431|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.43|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.43|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.429|
|[[:human genes:t:tyms|TYMS]]|0.428|
|[[:human genes:e:exosc5|EXOSC5]]|0.427|
|[[:human genes:c:ctr9|CTR9]]|0.427|
|[[:human genes:p:pan2|PAN2]]|0.427|
|[[:human genes:a:arcn1|ARCN1]]|0.427|
|[[:human genes:t:twistnb|TWISTNB]]|0.427|
|[[:human genes:r:rrn3|RRN3]]|0.426|
|[[:human genes:s:supt6h|SUPT6H]]|0.426|
|[[:human genes:i:ik|IK]]|0.425|
|[[:human genes:c:cbwd6|CBWD6]]|0.425|
|[[:human genes:s:ssh2|SSH2]]|0.425|
|[[:human genes:r:rad51|RAD51]]|0.424|
|[[:human genes:f:fam231a|FAM231A]]|0.423|
|[[:human genes:r:rps7|RPS7]]|0.423|
|[[:human genes:c:clcn6|CLCN6]]|0.423|
|[[:human genes:f:fam231c|FAM231C]]|0.423|
|[[:human genes:l:lrr1|LRR1]]|0.422|
|[[:human genes:a:aamp|AAMP]]|0.422|
|[[:human genes:s:sf3b2|SF3B2]]|0.42|
|[[:human genes:p:psmb1|PSMB1]]|0.42|
|[[:human genes:a:aqr|AQR]]|0.42|
|[[:human genes:c:col2a1|COL2A1]]|0.42|
|[[:human genes:p:polr2d|POLR2D]]|0.419|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.419|
|[[:human genes:n:nup54|NUP54]]|0.418|
|[[:human genes:p:psmd2|PSMD2]]|0.418|
|[[:human genes:t:tuba8|TUBA8]]|0.417|
|[[:human genes:t:traip|TRAIP]]|0.417|
|[[:human genes:a:atp13a1|ATP13A1]]|0.416|
|[[:human genes:k:kif3c|KIF3C]]|0.416|
|[[:human genes:d:ddtl|DDTL]]|0.416|
|[[:human genes:l:lad1|LAD1]]|0.416|
|[[:human genes:m:mdm2|MDM2]]|0.416|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.414|
|[[:human genes:z:znf574|ZNF574]]|0.414|
|[[:human genes:m:myt1l|MYT1L]]|0.413|
|[[:human genes:n:nupl1|NUPL1]]|0.412|
|[[:human genes:t:tfip11|TFIP11]]|0.412|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.411|
|[[:human genes:a:ankle2|ANKLE2]]|0.41|
|[[:human genes:c:ccdc116|CCDC116]]|0.41|
|[[:human genes:r:rrp15|RRP15]]|0.41|
|[[:human genes:c:cwc22|CWC22]]|0.41|
|[[:human genes:d:dock6|DOCK6]]|0.409|
|[[:human genes:m:mfsd12|MFSD12]]|0.409|
|[[:human genes:z:znf655|ZNF655]]|0.408|
|[[:human genes:a:abhd8|ABHD8]]|0.408|
|[[:human genes:c:cep192|CEP192]]|0.408|
|[[:human genes:m:msh5|MSH5]]|0.407|
|[[:human genes:b:bid|BID]]|0.407|
|[[:human genes:d:dand5|DAND5]]|0.406|
|[[:human genes:r:rad21|RAD21]]|0.406|
|[[:human genes:n:nop16|NOP16]]|0.405|
|[[:human genes:s:snrnp200|SNRNP200]]|0.405|
|[[:human genes:i:ints5|INTS5]]|0.405|
|[[:human genes:k:krt78|KRT78]]|0.404|
|[[:human genes:g:gga3|GGA3]]|0.404|
|[[:human genes:p:parp3|PARP3]]|0.404|
|[[:human genes:d:ddx56|DDX56]]|0.404|
|[[:human genes:c:cant1|CANT1]]|0.403|
|[[:human genes:s:supt5h|SUPT5H]]|0.403|
|[[:human genes:h:hivep3|HIVEP3]]|0.403|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.403|
|[[:human genes:e:exosc9|EXOSC9]]|0.401|
|[[:human genes:r:rpl38|RPL38]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 721/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|29/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1333
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST2H3A Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>