HIVEP3 [The Human Chemical-Genetic Interaction Map Project]

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======= HIVEP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIVEP3
  * **<color #00a2e8>Official Name</color>**: HIVEP zinc finger 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59269|59269]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T1R4|Q5T1R4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIVEP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIVEP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606649|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down- regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|skeletal muscle cell differentiation|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle structure development|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.14|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.86|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.83|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.78|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.79|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.545|
|[[:human genes:p:polr2j3|POLR2J3]]|0.544|
|[[:human genes:d:ddtl|DDTL]]|0.543|
|[[:human genes:c:ccna2|CCNA2]]|0.541|
|[[:human genes:t:tceb3c|TCEB3C]]|0.533|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.524|
|[[:human genes:c:cbwd5|CBWD5]]|0.516|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.516|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.514|
|[[:human genes:c:chd4|CHD4]]|0.513|
|[[:human genes:s:snip1|SNIP1]]|0.511|
|[[:human genes:c:cbwd3|CBWD3]]|0.508|
|[[:human genes:r:rad51|RAD51]]|0.502|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.5|
|[[:human genes:o:orc1|ORC1]]|0.496|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.487|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.487|
|[[:human genes:l:lrr1|LRR1]]|0.485|
|[[:human genes:r:rps12|RPS12]]|0.485|
|[[:human genes:r:rps5|RPS5]]|0.479|
|[[:human genes:p:psmc2|PSMC2]]|0.478|
|[[:human genes:c:cdca3|CDCA3]]|0.477|
|[[:human genes:n:nupl1|NUPL1]]|0.476|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.476|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.474|
|[[:human genes:r:rps2|RPS2]]|0.471|
|[[:human genes:a:aatf|AATF]]|0.471|
|[[:human genes:w:wdr75|WDR75]]|0.47|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.469|
|[[:human genes:k:kif3c|KIF3C]]|0.469|
|[[:human genes:k:kctd17|KCTD17]]|0.469|
|[[:human genes:s:slc4a1|SLC4A1]]|0.466|
|[[:human genes:t:tfip11|TFIP11]]|0.463|
|[[:human genes:a:ankle1|ANKLE1]]|0.462|
|[[:human genes:p:ppfia4|PPFIA4]]|0.461|
|[[:human genes:s:ssh2|SSH2]]|0.46|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.459|
|[[:human genes:s:smg7|SMG7]]|0.457|
|[[:human genes:s:s1pr4|S1PR4]]|0.457|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.456|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.456|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.456|
|[[:human genes:e:exd1|EXD1]]|0.454|
|[[:human genes:s:sec13|SEC13]]|0.453|
|[[:human genes:t:ticrr|TICRR]]|0.453|
|[[:human genes:p:polr2d|POLR2D]]|0.453|
|[[:human genes:c:cbwd6|CBWD6]]|0.45|
|[[:human genes:r:rps28|RPS28]]|0.449|
|[[:human genes:v:vasn|VASN]]|0.449|
|[[:human genes:p:pola1|POLA1]]|0.448|
|[[:human genes:n:narfl|NARFL]]|0.448|
|[[:human genes:c:copg1|COPG1]]|0.447|
|[[:human genes:p:pan2|PAN2]]|0.447|
|[[:human genes:w:wdr87|WDR87]]|0.446|
|[[:human genes:p:psmd1|PSMD1]]|0.445|
|[[:human genes:p:psmd3|PSMD3]]|0.443|
|[[:human genes:r:rrp7a|RRP7A]]|0.443|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.443|
|[[:human genes:k:krt78|KRT78]]|0.442|
|[[:human genes:p:pcf11|PCF11]]|0.441|
|[[:human genes:c:ccdc116|CCDC116]]|0.441|
|[[:human genes:l:lad1|LAD1]]|0.437|
|[[:human genes:z:zfand5|ZFAND5]]|0.437|
|[[:human genes:u:uqcrh|UQCRH]]|0.437|
|[[:human genes:r:riok2|RIOK2]]|0.435|
|[[:human genes:n:napa|NAPA]]|0.434|
|[[:human genes:s:slc6a17|SLC6A17]]|0.434|
|[[:human genes:r:ranbp2|RANBP2]]|0.434|
|[[:human genes:n:nol12|NOL12]]|0.433|
|[[:human genes:n:nop16|NOP16]]|0.431|
|[[:human genes:d:dock6|DOCK6]]|0.431|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.431|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.431|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.43|
|[[:human genes:c:cactin|CACTIN]]|0.43|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.43|
|[[:human genes:t:timeless|TIMELESS]]|0.43|
|[[:human genes:u:upf1|UPF1]]|0.429|
|[[:human genes:a:ankle2|ANKLE2]]|0.428|
|[[:human genes:g:gon4l|GON4L]]|0.426|
|[[:human genes:x:xab2|XAB2]]|0.425|
|[[:human genes:u:utp3|UTP3]]|0.425|
|[[:human genes:r:rbbp5|RBBP5]]|0.425|
|[[:human genes:s:supt6h|SUPT6H]]|0.425|
|[[:human genes:s:slc5a5|SLC5A5]]|0.425|
|[[:human genes:c:ctage4|CTAGE4]]|0.423|
|[[:human genes:t:traip|TRAIP]]|0.423|
|[[:human genes:c:cwc22|CWC22]]|0.423|
|[[:human genes:g:gar1|GAR1]]|0.422|
|[[:human genes:i:ik|IK]]|0.421|
|[[:human genes:d:ddt|DDT]]|0.421|
|[[:human genes:m:myt1l|MYT1L]]|0.421|
|[[:human genes:p:paf1|PAF1]]|0.42|
|[[:human genes:p:psmd7|PSMD7]]|0.42|
|[[:human genes:p:psmb2|PSMB2]]|0.42|
|[[:human genes:n:nup85|NUP85]]|0.419|
|[[:human genes:c:c14orf93|C14orf93]]|0.418|
|[[:human genes:h:hap1|HAP1]]|0.417|
|[[:human genes:l:loc643669|LOC643669]]|0.416|
|[[:human genes:s:sult2b1|SULT2B1]]|0.416|
|[[:human genes:d:dtl|DTL]]|0.416|
|[[:human genes:d:disp2|DISP2]]|0.416|
|[[:human genes:c:cln6|CLN6]]|0.414|
|[[:human genes:w:wdr43|WDR43]]|0.413|
|[[:human genes:c:chaf1a|CHAF1A]]|0.413|
|[[:human genes:p:pole|POLE]]|0.413|
|[[:human genes:p:psmc5|PSMC5]]|0.413|
|[[:human genes:s:supt5h|SUPT5H]]|0.412|
|[[:human genes:s:sart1|SART1]]|0.412|
|[[:human genes:d:dhfr|DHFR]]|0.412|
|[[:human genes:n:nup133|NUP133]]|0.412|
|[[:human genes:m:mt1e|MT1E]]|0.411|
|[[:human genes:p:pan3|PAN3]]|0.411|
|[[:human genes:r:rpl35|RPL35]]|0.411|
|[[:human genes:u:ubl5|UBL5]]|0.411|
|[[:human genes:t:terf2|TERF2]]|0.41|
|[[:human genes:r:rpl30|RPL30]]|0.409|
|[[:human genes:p:psma7|PSMA7]]|0.409|
|[[:human genes:c:clptm1|CLPTM1]]|0.409|
|[[:human genes:r:rps9|RPS9]]|0.409|
|[[:human genes:p:prss8|PRSS8]]|0.409|
|[[:human genes:c:ccdc94|CCDC94]]|0.409|
|[[:human genes:n:npipb5|NPIPB5]]|0.408|
|[[:human genes:e:exosc6|EXOSC6]]|0.408|
|[[:human genes:s:srgap2c|SRGAP2C]]|0.408|
|[[:human genes:p:psmb4|PSMB4]]|0.408|
|[[:human genes:t:tspy1|TSPY1]]|0.407|
|[[:human genes:c:cope|COPE]]|0.406|
|[[:human genes:r:rps7|RPS7]]|0.406|
|[[:human genes:t:tsg101|TSG101]]|0.405|
|[[:human genes:t:twistnb|TWISTNB]]|0.405|
|[[:human genes:t:tyms|TYMS]]|0.404|
|[[:human genes:s:sf3a1|SF3A1]]|0.404|
|[[:human genes:g:golga6b|GOLGA6B]]|0.404|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.403|
|[[:human genes:a:aqr|AQR]]|0.403|
|[[:human genes:n:nup153|NUP153]]|0.403|
|[[:human genes:o:orc6|ORC6]]|0.402|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.402|
|[[:human genes:p:psmc1|PSMC1]]|0.402|
|[[:human genes:c:chmp2a|CHMP2A]]|0.401|
|[[:human genes:r:rpl37a|RPL37A]]|0.401|
|[[:human genes:n:nsf|NSF]]|0.4|
|[[:human genes:s:snrpa1|SNRPA1]]|0.4|
|[[:human genes:a:acsf2|ACSF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1771
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIVEP3 Expression in NALM6 Cells: 6.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>