HMGA2 [The Human Chemical-Genetic Interaction Map Project]

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======= HMGA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HMGA2
  * **<color #00a2e8>Official Name</color>**: high mobility group AT-hook 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8091|8091]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52926|P52926]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HMGA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HMGA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600698|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H2A-S139 phosphorylation|
|MH1 domain binding|
|mesodermal-endodermal cell signaling|
|positive regulation of cellular response to X-ray|
|oncogene-induced cell senescence|
|MH2 domain binding|
|programmed DNA elimination|
|chromosome breakage|
|regulation of cellular response to X-ray|
|senescence-associated heterochromatin focus assembly|
|senescence-associated heterochromatin focus|
|histone H2A phosphorylation|
|5-deoxyribose-5-phosphate lyase activity|
|negative regulation of double-strand break repair via nonhomologous end joining|
|SMAD protein complex|
|regulation of cell proliferation in bone marrow|
|positive regulation of cell proliferation in bone marrow|
|AT DNA binding|
|heterochromatin assembly|
|chondrocyte proliferation|
|histone-serine phosphorylation|
|DNA-(apurinic or apyrimidinic site) endonuclease activity|
|positive regulation of cellular senescence|
|cAMP response element binding|
|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|negative regulation by host of viral transcription|
|positive regulation of cell aging|
|C2H2 zinc finger domain binding|
|heterochromatin organization|
|regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|mitotic G2 DNA damage checkpoint|
|negative regulation of cellular senescence|
|DNA binding, bending|
|negative regulation of cell aging|
|regulation of double-strand break repair via nonhomologous end joining|
|positive regulation of transcription regulatory region DNA binding|
|mesodermal cell differentiation|
|negative regulation of viral transcription|
|regulation of stem cell population maintenance|
|nuclear chromosome|
|mitotic G2/M transition checkpoint|
|histone phosphorylation|
|G2 DNA damage checkpoint|
|negative regulation of double-strand break repair|
|cellular senescence|
|negative regulation of DNA repair|
|regulation of cellular response to drug|
|base-excision repair|
|DNA damage response, detection of DNA damage|
|positive regulation of stem cell proliferation|
|endodermal cell differentiation|
|regulation of cellular senescence|
|chromosome condensation|
|protein-DNA complex|
|nucleosomal DNA binding|
|endoderm formation|
|regulation of cell aging|
|SMAD binding|
|regulation of transcription regulatory region DNA binding|
|negative regulation of DNA binding|
|positive regulation of DNA binding|
|negative regulation of viral genome replication|
|cell aging|
|regulation of viral transcription|
|regulation of stem cell proliferation|
|mesoderm formation|
|mesoderm morphogenesis|
|epithelial to mesenchymal transition|
|modification by host of symbiont morphology or physiology|
|endoderm development|
|interaction with symbiont|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|positive regulation of cell cycle arrest|
|negative regulation of viral life cycle|
|chondrocyte differentiation|
|transcription coregulator activity|
|negative regulation of G2/M transition of mitotic cell cycle|
|regulation of viral genome replication|
|mitotic DNA damage checkpoint|
|negative regulation of viral process|
|regulation of response to drug|
|positive regulation of response to DNA damage stimulus|
|negative regulation of cell cycle G2/M phase transition|
|mitotic DNA integrity checkpoint|
|fat cell differentiation|
|regulation of cell cycle arrest|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|formation of primary germ layer|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|mesoderm development|
|regulation of DNA binding|
|DNA damage checkpoint|
|chromatin assembly|
|DNA integrity checkpoint|
|regulation of viral life cycle|
|mitotic cell cycle checkpoint|
|modification of morphology or physiology of other organism|
|chromatin assembly or disassembly|
|mesenchymal cell differentiation|
|stem cell differentiation|
|gastrulation|
|chromatin remodeling|
|positive regulation of angiogenesis|
|negative regulation of binding|
|cartilage development|
|peptidyl-serine phosphorylation|
|DNA packaging|
|positive regulation of binding|
|positive regulation of vasculature development|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|peptidyl-serine modification|
|regulation of viral process|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of multi-organism process|
|transcription regulatory region DNA binding|
|regulation of response to DNA damage stimulus|
|regulation of symbiosis, encompassing mutualism through parasitism|
|mesenchyme development|
|connective tissue development|
|negative regulation of cell cycle phase transition|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|aging|
|response to virus|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|DNA conformation change|
|negative regulation of mitotic cell cycle|
|regulation of vasculature development|
|negative regulation of cell cycle process|
|transcription factor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|positive regulation of cell cycle|
|regulation of binding|
|regulation of mitotic cell cycle phase transition|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of cell cycle phase transition|
|cell division|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of growth|
|mitotic cell cycle|
|detection of stimulus|
|positive regulation of cell death|
|chromatin organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|negative regulation of cell death|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15382
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HMGA2 Expression in NALM6 Cells: 2.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>