HMOX1 [The Human Chemical-Genetic Interaction Map Project]

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======= HMOX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HMOX1
  * **<color #00a2e8>Official Name</color>**: heme oxygenase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3162|3162]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09601|P09601]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HMOX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HMOX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/141250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Heme oxygenase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|muscle hyperplasia|
|smooth muscle hyperplasia|
|negative regulation of mast cell cytokine production|
|heme oxidation|
|regulation of transcription from RNA polymerase II promoter in response to iron|
|heme oxygenase (decyclizing) activity|
|smooth muscle adaptation|
|regulation of mast cell cytokine production|
|cellular response to cisplatin|
|wound healing involved in inflammatory response|
|negative regulation of mast cell degranulation|
|tetrapyrrole catabolic process|
|phospholipase D activity|
|inflammatory response to wounding|
|heme catabolic process|
|porphyrin-containing compound catabolic process|
|pigment catabolic process|
|response to cisplatin|
|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|negative regulation of mast cell activation involved in immune response|
|cellular response to iron ion|
|negative regulation of myeloid leukocyte mediated immunity|
|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|positive regulation of chemokine biosynthetic process|
|negative regulation of leukocyte degranulation|
|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|negative regulation of mast cell activation|
|regulation of chemokine biosynthetic process|
|negative regulation of vascular smooth muscle cell proliferation|
|cellular response to arsenic-containing substance|
|positive regulation of cell migration involved in sprouting angiogenesis|
|endothelial cell proliferation|
|low-density lipoprotein particle clearance|
|negative regulation of regulated secretory pathway|
|negative regulation of cytokine production involved in immune response|
|liver regeneration|
|heme metabolic process|
|response to arsenic-containing substance|
|muscle adaptation|
|negative regulation of macroautophagy|
|response to iron ion|
|negative regulation of exocytosis|
|regulation of mast cell degranulation|
|negative regulation of production of molecular mediator of immune response|
|regulation of mast cell activation involved in immune response|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of muscle cell apoptotic process|
|cellular response to cadmium ion|
|porphyrin-containing compound metabolic process|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of sprouting angiogenesis|
|plasma lipoprotein particle clearance|
|excretion|
|negative regulation of epithelial cell apoptotic process|
|negative regulation of leukocyte migration|
|negative regulation of smooth muscle cell proliferation|
|regulation of mast cell activation|
|regulation of leukocyte degranulation|
|response to nicotine|
|negative regulation of leukocyte mediated immunity|
|regulation of vascular smooth muscle cell proliferation|
|negative regulation of DNA binding|
|positive regulation of blood vessel endothelial cell migration|
|positive regulation of chemokine production|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of blood vessel diameter|
|regulation of myeloid leukocyte mediated immunity|
|tetrapyrrole metabolic process|
|negative regulation of intracellular transport|
|cofactor catabolic process|
|cellular iron ion homeostasis|
|response to cadmium ion|
|pigment metabolic process|
|positive regulation of cytokine biosynthetic process|
|cellular response to nutrient|
|positive regulation of macroautophagy|
|regulation of muscle cell apoptotic process|
|regulation of sprouting angiogenesis|
|cellular response to heat|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of plasma lipoprotein particle levels|
|animal organ regeneration|
|caveola|
|response to estrogen|
|regulation of chemokine production|
|regulation of epithelial cell apoptotic process|
|iron ion homeostasis|
|negative regulation of autophagy|
|regulation of cytokine production involved in immune response|
|positive regulation of smooth muscle cell proliferation|
|epithelial cell proliferation|
|erythrocyte homeostasis|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell proliferation|
|response to antineoplastic agent|
|positive regulation of endothelial cell migration|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of cytokine biosynthetic process|
|myeloid cell homeostasis|
|cellular transition metal ion homeostasis|
|response to heat|
|response to hydrogen peroxide|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|positive regulation of autophagy|
|negative regulation of immune effector process|
|liver development|
|regulation of DNA binding|
|regulation of DNA-templated transcription in response to stress|
|regulation of endothelial cell proliferation|
|hepaticobiliary system development|
|transition metal ion homeostasis|
|regulation of smooth muscle cell proliferation|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|regulation of production of molecular mediator of immune response|
|positive regulation of epithelial cell migration|
|heme binding|
|negative regulation of neuron apoptotic process|
|negative regulation of immune response|
|intrinsic apoptotic signaling pathway|
|regulation of extrinsic apoptotic signaling pathway|
|regeneration|
|regulation of endothelial cell migration|
|negative regulation of DNA-binding transcription factor activity|
|regulation of regulated secretory pathway|
|positive regulation of angiogenesis|
|vascular process in circulatory system|
|negative regulation of binding|
|regulation of macroautophagy|
|negative regulation of leukocyte activation|
|response to temperature stimulus|
|regulation of blood pressure|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to hypoxia|
|positive regulation of epithelial cell proliferation|
|cellular response to metal ion|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|cellular response to decreased oxygen levels|
|homeostasis of number of cells|
|negative regulation of secretion by cell|
|regulation of leukocyte mediated immunity|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|response to nutrient|
|positive regulation of immune effector process|
|cellular response to inorganic substance|
|regulation of epithelial cell migration|
|regulation of exocytosis|
|negative regulation of apoptotic signaling pathway|
|negative regulation of secretion|
|cellular response to nutrient levels|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to oxidative stress|
|negative regulation of cellular catabolic process|
|negative regulation of cell migration|
|cellular response to extracellular stimulus|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|muscle system process|
|response to antibiotic|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|regulation of neuron death|
|angiogenesis|
|small GTPase mediated signal transduction|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of autophagy|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|protein homooligomerization|
|response to hypoxia|
|enzyme binding|
|regulation of intracellular transport|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|response to metal ion|
|regulation of binding|
|response to oxygen levels|
|response to oxidative stress|
|blood circulation|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|blood vessel morphogenesis|
|gland development|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|cofactor metabolic process|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|positive regulation of cytokine production|
|regulation of immune effector process|
|wound healing|
|organic cyclic compound catabolic process|
|negative regulation of transport|
|blood vessel development|
|response to nutrient levels|
|inflammatory response|
|positive regulation of cell migration|
|response to toxic substance|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|protein complex oligomerization|
|positive regulation of cell motility|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|cellular metal ion homeostasis|
|response to wounding|
|regulation of leukocyte activation|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|cellular response to DNA damage stimulus|
|ion homeostasis|
|regulation of secretion|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|nucleolus|
|circulatory system development|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|apoptotic process|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|cell death|
|response to cytokine|
|chemical homeostasis|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.519|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9542
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HMOX1 Expression in NALM6 Cells: 0.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>