HNMT [The Human Chemical-Genetic Interaction Map Project]

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======= HNMT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNMT
  * **<color #00a2e8>Official Name</color>**: histamine N-methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3176|3176]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50135|P50135]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNMT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNMT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605238|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. {ECO:0000269|PubMed:26206890}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histamine N-methyltransferase activity|
|histamine catabolic process|
|histamine metabolic process|
|imidazole-containing compound catabolic process|
|histidine catabolic process|
|histidine metabolic process|
|response to tumor cell|
|imidazole-containing compound metabolic process|
|cellular biogenic amine catabolic process|
|amine catabolic process|
|neurotransmitter catabolic process|
|hyperosmotic response|
|response to immobilization stress|
|aromatic amino acid family catabolic process|
|aromatic amino acid family metabolic process|
|respiratory gaseous exchange by respiratory system|
|response to amine|
|response to cocaine|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|amine metabolic process|
|response to osmotic stress|
|response to anesthetic|
|neurotransmitter metabolic process|
|alpha-amino acid catabolic process|
|response to alkaloid|
|cellular amino acid catabolic process|
|response to glucocorticoid|
|response to corticosteroid|
|response to ammonium ion|
|ammonium ion metabolic process|
|response to interleukin-1|
|alpha-amino acid metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|response to xenobiotic stimulus|
|cellular amino acid metabolic process|
|methylation|
|neuron projection|
|response to steroid hormone|
|regulation of neurotransmitter levels|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|brain development|
|head development|
|response to lipid|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|central nervous system development|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|response to cytokine|
|response to abiotic stimulus|
|response to biotic stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12393
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNMT Expression in NALM6 Cells: 1.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>