HNRNPA1 [The Human Chemical-Genetic Interaction Map Project]

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======= HNRNPA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPA1
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3178|3178]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09651|P09651]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164017|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:28431233}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|HnRNPA1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|telomeric repeat-containing RNA binding|
|cellular response to sodium arsenite|
|response to sodium arsenite|
|cellular response to salt|
|G-rich strand telomeric DNA binding|
|response to herbicide|
|pre-mRNA binding|
|response to insecticide|
|response to salt|
|cellular response to arsenic-containing substance|
|negative regulation of telomere maintenance via telomerase|
|negative regulation of telomere maintenance via telomere lengthening|
|miRNA binding|
|response to arsenic-containing substance|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomere maintenance via telomere lengthening|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|cellular response to glucose starvation|
|single-stranded RNA binding|
|positive regulation of telomere maintenance|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|regulation of alternative mRNA splicing, via spliceosome|
|positive regulation of DNA biosynthetic process|
|fibroblast growth factor receptor signaling pathway|
|regulation of telomere maintenance|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|response to antineoplastic agent|
|regulation of mRNA splicing, via spliceosome|
|single-stranded DNA binding|
|cellular response to fibroblast growth factor stimulus|
|regulation of DNA biosynthetic process|
|import into nucleus|
|response to fibroblast growth factor|
|cellular response to antibiotic|
|negative regulation of DNA metabolic process|
|RNA export from nucleus|
|negative regulation of chromosome organization|
|regulation of RNA splicing|
|regulation of mRNA processing|
|cellular response to starvation|
|ribonucleoprotein complex|
|mRNA transport|
|nuclear export|
|mRNA binding|
|positive regulation of chromosome organization|
|RNA transport|
|nucleic acid transport|
|response to starvation|
|positive regulation of DNA metabolic process|
|establishment of RNA localization|
|cellular response to toxic substance|
|RNA localization|
|cellular response to nutrient levels|
|nucleobase-containing compound transport|
|protein domain specific binding|
|nucleocytoplasmic transport|
|cellular response to extracellular stimulus|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|response to antibiotic|
|regulation of mRNA metabolic process|
|cellular response to external stimulus|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|RNA splicing|
|cellular response to drug|
|mRNA processing|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to extracellular stimulus|
|response to growth factor|
|response to inorganic substance|
|positive regulation of organelle organization|
|mRNA metabolic process|
|viral process|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|response to drug|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.82|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.71|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.71|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.73|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.79|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.81|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.06|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.14|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.22|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.457|
|[[:human genes:v:vasn|VASN]]|0.455|
|[[:human genes:n:numa1|NUMA1]]|0.451|
|[[:human genes:d:disp2|DISP2]]|0.446|
|[[:human genes:a:atp1a3|ATP1A3]]|0.446|
|[[:human genes:c:copg1|COPG1]]|0.439|
|[[:human genes:t:tceb3c|TCEB3C]]|0.433|
|[[:human genes:p:psmb4|PSMB4]]|0.433|
|[[:human genes:c:cbwd3|CBWD3]]|0.432|
|[[:human genes:c:copa|COPA]]|0.43|
|[[:human genes:i:iscu|ISCU]]|0.424|
|[[:human genes:p:pcf11|PCF11]]|0.423|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.422|
|[[:human genes:p:psap|PSAP]]|0.422|
|[[:human genes:s:sf3a1|SF3A1]]|0.421|
|[[:human genes:a:aamp|AAMP]]|0.421|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.42|
|[[:human genes:k:kif3c|KIF3C]]|0.419|
|[[:human genes:n:npipb5|NPIPB5]]|0.416|
|[[:human genes:s:scaf1|SCAF1]]|0.414|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.413|
|[[:human genes:d:ddtl|DDTL]]|0.413|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.412|
|[[:human genes:m:mt1e|MT1E]]|0.412|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.411|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.41|
|[[:human genes:n:napa|NAPA]]|0.408|
|[[:human genes:c:cbwd5|CBWD5]]|0.408|
|[[:human genes:h:hap1|HAP1]]|0.407|
|[[:human genes:r:ranbp2|RANBP2]]|0.405|
|[[:human genes:m:med29|MED29]]|0.403|
|[[:human genes:r:rbm39|RBM39]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1538
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPA1 Expression in NALM6 Cells: 10.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>