HNRNPK [The Human Chemical-Genetic Interaction Map Project]

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======= HNRNPK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPK
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3190|3190]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61978|P61978]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600712|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ROKNT|
|KH 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter|
|positive regulation of low-density lipoprotein particle receptor biosynthetic process|
|regulation of lipid transport by regulation of transcription from RNA polymerase II promoter|
|regulation of low-density lipoprotein particle receptor biosynthetic process|
|regulation of low-density lipoprotein particle clearance|
|positive regulation of receptor biosynthetic process|
|regulation of lipoprotein particle clearance|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|negative regulation of mRNA splicing, via spliceosome|
|regulation of receptor biosynthetic process|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|podosome|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of receptor-mediated endocytosis|
|cytoplasmic stress granule|
|negative regulation of mRNA metabolic process|
|catalytic step 2 spliceosome|
|cell projection|
|regulation of mRNA splicing, via spliceosome|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|single-stranded DNA binding|
|regulation of lipid transport|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of lipid localization|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of signal transduction by p53 class mediator|
|regulation of endocytosis|
|regulation of response to DNA damage stimulus|
|nuclear chromatin|
|protein domain specific binding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|cadherin binding|
|regulation of mRNA metabolic process|
|RNA splicing|
|regulation of apoptotic signaling pathway|
|focal adhesion|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|mRNA processing|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of vesicle-mediated transport|
|mRNA metabolic process|
|viral process|
|regulation of cellular response to stress|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of transport|
|negative regulation of cell death|
|identical protein binding|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.26|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.92|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.89|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.79|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.71|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.71|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 549
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPK Expression in NALM6 Cells: 9.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>